Dietary lactose and galactose intakes are associated with a later onset of natural menopause among women in a Japanese community
Dietary lactose and galactose intakes are associated with a later onset of natural menopause among women in a Japanese community
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DOI：
10.1017/s0007114522002586
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发表时间：
2022-08
影响因子：
3.6
通讯作者：
M. Yamakawa;K. Wada;Yuma Nakashima;C. Nagata
中科院分区：
文献类型：
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作者：
M. Yamakawa;K. Wada;Yuma Nakashima;C. Nagata
摘要半乳糖及其代谢产物，主要来源于乳糖，可能对卵巢有毒性作用。我们的目的是前瞻性地研究半乳糖和乳糖摄入量与自然绝经期的关系。对1992年在日本社区开展的一项基于人群的队列研究（高山研究）的数据进行了分析，并于2002年收集了随访数据。在Takayama研究的参与者中，基线时年龄为35-56岁的绝经前女性（n 3115）被纳入本研究。仅在基线时使用FFQ评估饮食摄入量，包括乳糖和半乳糖。根据参与者的自我报告确定绝经状态和绝经年龄，自然绝经定义为12个月或更长时间没有月经。使用考克斯比例风险模型估计风险比（HR）和95% CI。在10年的随访中，共有1790名妇女经历了自然绝经。在调整潜在混杂因素后，乳糖和半乳糖摄入量与自然绝经期延迟相关，乳糖和半乳糖的最高和最低四分位数的HR（95% CI）分别为0·80（0·69，0·92）（P趋势= 0·001）和0·86（0·74，1·00）（P趋势= 0·036）。乳糖和半乳糖的高摄入量与自然绝经期的延迟有关。尽管假定的卵毒性作用，乳糖和半乳糖摄入量在正常水平可能不会对卵巢衰老过程中的日本社区居住的妇女。
Abstract Galactose and its metabolites, primarily derived from lactose, may have toxic effects on the ovary. We aimed to prospectively examine the associations of galactose and lactose intakes with the onset of natural menopause. The data of a population-based cohort study in a Japanese community (the Takayama study) initiated in 1992 were analysed, with follow-up data collected in 2002. Among the participants of the Takayama study, premenopausal women (n 3115) aged 35–56 years at baseline were included in this study. Dietary intake, including lactose and galactose was assessed only at baseline using a FFQ. The menopausal status and age at menopause were determined based on the participants’ self-reports, and natural menopause was defined as the absence of menstruation for 12 months or more. Cox proportional hazards models were used to estimate the hazard ratios (HR) and 95 % CI. A total of 1790 women experienced natural menopause within the 10-year follow-up. Lactose and galactose intakes were associated with a later onset of natural menopause after adjusting for potential confounding factors and the HR (95 % CI) for the highest v. lowest quartile were 0·80 (0·69, 0·92) (P-trend = 0·001) in lactose and 0·86 (0·74, 1·00) in galactose (P-trend = 0·036), respectively. High intakes of lactose and galactose were associated with a later onset of natural menopause. Despite the presumed ovotoxicity effects, lactose and galactose intakes at usual levels may not be deleterious to the ovarian aging process among Japanese community-dwelling women.