Temperature sensitivity of two-pore (K2P) potassium channels.
Temperature sensitivity of two-pore (K2P) potassium channels.
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DOI：
10.1016/b978-0-12-800181-3.00005-1
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发表时间：
2014
影响因子：
--
通讯作者：
Bagriantsev SN
中科院分区：
文献类型：
--
作者：
Schneider ER;Anderson EO;Gracheva EO;Bagriantsev SN
在正常体温下，双孔钾通道TREK-1 （K2P2.1/KCNK2）、TREK-2 （K2P10.1/KCNK10）和TRAAK （K2P4.1/KCNK2）通过提供电压无关的钾泄漏来调节细胞的兴奋性。热量显著增强K2P通道活动，并进一步影响激发。本文综述了热激活K2P电流的生理作用，并讨论了TREK-1、TREK-2和TRAAK中温度门控的分子机制。
At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Heat dramatically potentiates K2P channel activity and further affects excitation. This review focuses on the current understanding of the physiological role of heat-activated K2P current, and discusses the molecular mechanism of temperature gating in TREK-1, TREK-2, and TRAAK.