ON CROSS REACTIONS OF IMMUNE SERA TO AZOPROTEINS.
ON CROSS REACTIONS OF IMMUNE SERA TO AZOPROTEINS.
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DOI：
10.1084/jem.63.3.325
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发表时间：
1936-02-29
期刊：
影响因子：
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通讯作者：
van der Scheer J
中科院分区：
文献类型：
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作者：
Landsteiner K;van der Scheer J
在免疫血清对具有异源偶氮抗原的偶氮蛋白的吸收上观察到的现象导致以下结论：一般而言，血清不包含单一抗体，而是抗体组分在它们对异源抗原的反应性方面有些不同。从偶氮组分的构成可以看出，这些馏分不能特异性地用于分子中的不同化学基团。事实上，抑制实验表明，在所检查的情况下，各种抗体都特异性地针对同源半抗原的整个分子。
The phenomena observed on absorption of immune sera to azoproteins with heterologous azoantigens lead to the conclusion that in general the sera do not contain a single antibody but antibody fractions somewhat different in their reactivity for heterologous antigens. From the constitution of the azocomponent it follows that these fractions cannot be specific for distinct chemical groups in the molecule. In fact, inhibition experiments showed that in the cases examined the various antibodies are all specifically directed towards the whole molecule of the homologous hapten.