Body weight and weight gain related to pulmonary function decline in adults: a six year follow up study.

Body weight and weight gain related to pulmonary function decline in adults: a six year follow up study.
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体重和体重增加与成人肺功能下降相关：一项六年的随访研究。

DOI：
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发表时间：
1993
期刊：
Thorax
影响因子：
10
通讯作者：
J. A. Dosman
J. A. Dosman
中科院分区：
医学1区
文献类型：
--
作者：
Y. Chen;S. Horne;J. A. Dosman

文献摘要

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背景 肥胖会增加患心血管疾病、高血压、糖尿病、消化系统疾病和某些癌症的风险。多项研究表明，体重过多或体重增加与肺功能障碍有关，但这一问题需要进一步明确。 方法 该分析基于在加拿大萨斯喀彻温省洪堡镇进行的洪堡队列研究的数据。1977年的基线调查包括1202名成年人，占所有25-59岁居民的94%。其中709例（59%）于1983年随访。两次调查均测量肺功能（用力肺活量（FVC）、第一秒用力呼气量（FEV 1）和最大呼气中段流速（MMFR））和体重。通过从随访时的体重减去基线时的体重来确定体重增加。残差分析用于检查基线体重指数（BMI）、体重增加和肺功能下降之间的关系。 结果 基线时的BMI和体重增加与随访时的肺功能显著相关。然而，研究期间体重增加的影响更为突出。结果显示，在考虑年龄、基线BMI和吸烟因素后，男性和女性的平均剩余FVC和FEV 1在体重增加< 1.0 kg的组中最高，在体重增加≥ 4.0 kg的组中最低，在体重增加1.0-3.9 kg的组中居中。体重增加对肺功能的影响男性大于女性。多元回归分析显示，体重每增加1 kg，男性FVC和FEV 1分别减少26 ml和23 ml，女性分别减少14 ml和9 ml。 结论 体重增加与肺功能障碍显著相关。体重增加对肺功能的影响男性大于女性。
BACKGROUND Obesity increases the risk of cardiovascular disease, hypertension, diabetes, digestive diseases, and some cancers. Several studies have shown that excess weight or weight gain is related to pulmonary dysfunction, but this issue needs to be further clarified. METHODS The analysis was based on data of the Humboldt cohort study which was conducted in the town of Humboldt, Saskatchewan, Canada. The baseline survey in 1977 included 1202 adults, comprising 94% of all residents aged 25-59 years. Of these, 709 (59%) were followed up in 1983. Pulmonary function (forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and maximal mid expiratory flow rate (MMFR) and weight were measured in both surveys. Weight gain was determined by subtracting weight at baseline from weight at follow up. A residual analysis was used to examine the relationship between body mass index (BMI) at baseline, weight gain, and pulmonary function decline. RESULTS Both BMI at baseline and weight gain were significantly related to pulmonary function at follow up. The effect of weight gain during the study period, however, was more prominent. The results showed that both mean residual FVC and FEV1 were highest in the group that gained < 1.0 kg, lowest in the group that gained > or = 4.0 kg, and intermediate in the group that gained 1.0-3.9 kg in both men and women after taking age, BMI at baseline, and smoking into account. The effect of weight gain on pulmonary function was greater in men than in women. Multiple regression analysis showed that each kilogram of weight gain was associated with an excess loss of 26 ml in FVC and 23 ml in FEV1 in men, and 14 ml and 9 ml respectively in women. CONCLUSIONS Weight gain is significantly related to lung dysfunction. The effect of weight gain on pulmonary function is greater in men than in women.