Relative effects of cigarette smoke and ethanol on acute platelet thrombus formation in stenosed canine coronary arteries.
Relative effects of cigarette smoke and ethanol on acute platelet thrombus formation in stenosed canine coronary arteries.
复制标题
香烟烟雾和乙醇对狭窄犬冠状动脉急性血小板血栓形成的相对影响。
DOI：
10.1093/cvr/22.1.73
复制
发表时间：
1988
影响因子：
10.8
通讯作者：
Folts,JD
中科院分区：
文献类型：
--
作者：
Keller,JW;Folts,JD
在10只冠状动脉机械狭窄的开胸犬中，急性血小板血栓形成并随后栓塞使冠状动脉血流量周期性减少-10.2(3.3)ml·min - 2（用电磁流量探头测量）。用香烟烟雾给狗通风使流量减少到-13.5(4.6)ml·min−2。乙醇1.0 ml·kg - 1iv完全消除了所有10只狗的急性血栓形成和血流减少。在10只狗中，有9只狗在使用乙醇无法恢复血流减少后，重复使用香烟烟雾进行通气。这表明，当两者同时使用时，乙醇有效地抑制了香烟烟雾对急性血小板血栓形成的加剧作用。
In 10 open chest dogs with mechanically stenosed coronary arteries acute platelet thrombus formation with subsequent embolisation reduced coronary blood flow cyclically by -10.2(3.3) ml·min−2(as measured with an electromagnetic flow probe). Ventilating the dogs with cigarette smoke increased the flow reductions to -13.5(4.6) ml·min−2. Ethanol 1.0 ml·kg−1iv completely abolished acute thrombus formation and flow reductions in all 10 dogs. Repeat ventilation with cigarette smoke after ethanol failed to renew flow reductions in nine of the 10 dogs. It is suggested that ethanol effectively inhibits the exacerbating effects of cigarette smoke on acute platelet thrombus formation when both are being used simultaneously.