Biophysically defined and cytocompatible covalently adaptable networks as viscoelastic 3D cell culture systems.
Biophysically defined and cytocompatible covalently adaptable networks as viscoelastic 3D cell culture systems.
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DOI：
10.1002/adma.201303680
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发表时间：
2014-02-12
期刊：
影响因子：
--
通讯作者：
Anseth KS
中科院分区：
文献类型：
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作者：
McKinnon DD;Domaille DW;Cha JN;Anseth KS
这里提出了一种细胞相容的共价适应性水凝胶，能够独特地模拟自然组织的复杂生物物理性质，并使自然细胞功能不会降解基质。证明了在根据基本的理论理解和肌肉组织的模拟以及成肌细胞的包裹来预测这些值的同时，能够将弹性模量和应力松弛时间常数控制在一个数量级以上的能力。
Presented here is a cytocompatible covalently adaptable hydrogel uniquely capable of mimicking the complex biophysical properties of native tissue and enabling natural cell functions without matrix degradation. Demonstrated is both the ability to control elastic modulus and stress relaxation time constants by more than an order of magnitude while predicting these values based on fundamental theoretical understanding and the simulation of muscle tissue and the encapsulation of myoblasts.