Effects of acute alcohol ingestion on neuromotor functions
Effects of acute alcohol ingestion on neuromotor functions
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DOI：
10.1016/j.neuro.2008.04.018
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发表时间：
2008-07-01
期刊：
影响因子：
3.4
通讯作者：
Murata, Katsuyuki
中科院分区：
文献类型：
--
作者：
Ando, Shunpei;Iwata, Toyoto;Murata, Katsuyuki
为了研究急性酒精摄入对神经运动的影响，在13名20-22岁（平均20.7岁）的健康志愿者摄入酒精或果汁之前和之后测量了姿势摇摆、手震颤和反应时间。受试者消耗的乙醇剂量（平均值+/-SD）为0.59 +/- 0.07 g/kg体重，乙醇摄入后30 min时血液乙醇浓度估计为0.86 +/- 0.23 g/l：70 min时为0.88 +/- 0.19 g/l：130分钟时为0.74 +/- 0.27 g/l。酒精摄入后1小时和2小时的摇摆面积、总横向摇摆（Dx）和0-1 Hz闭眼时Dx的变化显著大于果汁摄入后。同样，2小时的变化摇摆面积，总Dx，Dx在0-1 Hz与眼睛打开后，酒精摄入后比果汁摄入后显着更大。酒精和果汁摄入之间在手震颤或反应时间的变化方面没有显着差异。这些数据表明，静态平衡，由于急性酒精摄入的特点是主要的横向摆动的低频（0-1赫兹）与闭上眼睛，这似乎不同于酗酒者的姿势摇摆的特点。(C)2008年爱思唯尔公司All rights reserved.
To scrutinize the neuromotor effects of acute alcohol ingestion, postural sway, hand tremor, and reaction time were measured before and after alcohol or juice ingestion in 13 healthy volunteers at 20-22 years (mean 20.7) of age. The dose of ethanol consumed by the subjects (mean +/- S.D.) was 0.59 +/- 0.07 g/kg body weight, and the blood ethanol concentrations were estimated to be 0.86 +/- 0.23 g/l at 30 min after ethanol ingestion: 0.88 +/- 0.19 g/l at 70 min: 0.74 +/- 0.27 g/l at 130 min. The 1-h and 2-h changes in sway area, total transversal sway (Dx), and Dx at 0-1 Hz with eyes closed were significantly larger after alcohol ingestion than after juice ingestion. Similarly, the 2-h changes in sway area, total Dx, and Dx at 0-1 Hz with eyes open were significantly larger after alcohol ingestion than after juice ingestion. No significant differences were seen between alcohol and juice ingestion regarding changes in hand tremor or reaction time. These data suggest that the static balance due to acute alcohol ingestion is characterized mainly by transversal sway of low frequency (0-1 Hz) with eyes closed, which seems to differ from the characteristics of postural sway in alcoholics. (C) 2008 Elsevier Inc. All rights reserved.