Irish funder guidance increased searching for, and uptake of, core outcome sets.
Irish funder guidance increased searching for, and uptake of, core outcome sets.
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爱尔兰资助者的指导增加了对核心成果集的搜索和采用。
DOI：
10.1016/j.jclinepi.2023.03.019
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发表时间：
2023
影响因子：
7.2
通讯作者：
Beecher C
中科院分区：
文献类型：
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作者：
Beecher C
目的评估爱尔兰健康研究委员会（HRB）指南对核心结果集（COS）的影响。研究设计和设置（1）COS使用信息，有效性试验核心结果测量（COMET）数据库的搜索，和成果选择的基本原理是从人力资源机构的资金申请中提取的（2）COMET在申请时搜索相关COS的可用性或自申请以来开发的相关COS的可用性（3）主要研究者的选择通过在线调查进行了探讨。结果在187项资助申请中，44%（n= 82）的人搜索了COMET数据库，13%（n= 11）的人找到了相关的COS来告知他们的结果。四个申请人提出了COS开发。然而，84%（n= 156）的申请在提交时没有相关的COS，这是由随后的作者COMET搜索确定的。在参与调查的84名主要调查者中，10名（12%）发现并使用了COS，45名没有参考COMET的受访者中有19名（42%）搜索了COMET数据库。申请表中的一个新问题促使那些报告检索COMET数据库的人从6%上升到99%.ConclusionThe研究发现在资助申请中COS摄取率较低，但一个新的申请问题促使报告检索COMET数据库的人数增加。Funder的指导促进了COS的认识和使用，但还需要更多的努力来促进COS的开发和临床研究的采用。
ObjectivesAssess the impact of the Health Research Board (HRB) Ireland guidance on the uptake of core outcome sets (COSs).Study Design and Setting(1) Information on COS use, searching of the Core Outcome Measures in Effectiveness Trials (COMET) database, and rationale for outcome selection were extracted from HRB funding applications (2) COMET was searched for relevant COS availability at the time of application or developed since (3) principal investigator choices were explored through online surveys.ResultsOut of 187 funding applications, 44% (n= 82) searched the COMET database, and 13% (n= 11) of those found a relevant COS to inform their outcomes. Four applicants proposed COS development. However, 84% (n= 156) of applications had no relevant COS available at the time of submission, as identified by subsequent author COMET search. Among 84 principal investigators who participated in the surveys, 10 (12%) found and used a COS and 19 (42%) of the 45 respondents who did not have reference to COMET had searched the COMET database. A new question in the application form prompted a rise in those reporting a search of the COMET database from 6% to 99%.ConclusionThe study found low COS uptake in funding applications, but a new application question prompted an increase in reporting searches of the COMET database. Funder guidance promoted COS awareness and use, but more efforts are needed to facilitate COS development and adoption in clinical research.