Risk of testicular cancer in men with abnormal semen characteristics:: cohort study
Risk of testicular cancer in men with abnormal semen characteristics:: cohort study
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DOI：
10.1136/bmj.321.7264.789
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发表时间：
2000-09-30
影响因子：
105.7
通讯作者：
Moller, H
中科院分区：
文献类型：
--
作者：
Jacobsen, R;Bostofte, E;Moller, H
目的探讨精液特征与睾丸癌发病风险的关系。研究设计：队列研究。研究对象为1963年至1999年在哥本哈根精子分析实验室进行精液分析的32442名男性。95.主要结果测量与丹麦男性总人口相比，睾丸癌的标准化发病率。癌症比其他男性（89例，标准化发病率比1.6; 95%置信区间1.3至1.9）。随着精液分析和癌症诊断之间时间的增加，风险相对恒定。根据特定精液特征进行的分析表明，精液浓度低（标准化发病率为2.3）、精子活动力差（2.5）和形态异常精子比例高（3.0）均与睾丸癌风险增加相关。其他癌症组中，只有腹膜和其他消化器官（6例; 3.7，1.3 - 8.0）的发病率有所下降。其中，两例可能和两例可能是性腺外生殖细胞的rumands.Conclusions的结果指向存在共同的病因因素，精液质量低，睾丸癌。精液质量低也可能与性腺外生殖细胞肿瘤的发病率增加有关。
Objective To explore the associations between semen characteristics and subsequent risk of testicular cancer.Design Cohort studyParticipants 32 442 men who had a semen analysis done at the Sperm Analysis Laboratory in Copenhagen during 1963-95.Main outcome measure Standardised incidence ratios of testicular cancer compared with total population of Danish men.Results Men in couples with fertility problems were more likely to develop testicular cancer than other men (89 cases, standardised incidence ratio 1.6; 95% confidence interval 1.3 to 1.9). The risk was relatively constant with increasing time between semen analysis and cancer diagnosis. Analysis according to specific semen characteristics showed that low semen concentration (standardised incidence ratio 2.3), poor motility of the spermatozoa (2.5), and high proportion of morphologically abnormal spermatozoa (3.0) were all associated with an increased risk of testicular cancer. The only other cancer group that showed ina eased incidence was "peritoneum and other digestive organs (six cases; 3.7, 1.3 to 8.0). Of these, two cases were probably and two cases were possibly extragonadal germ cell rumours.Conclusions The results point towards the existence of common aetiological factors for low semen quality and testicular cancer. Low semen quality may also be associated with increased incidence of extragonadal germ cell tumours.