Developmental changes in P1 and N1 central auditory responses elicited by consonant-vowel syllables
Developmental changes in P1 and N1 central auditory responses elicited by consonant-vowel syllables
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DOI：
10.1016/s0168-5597(97)00050-6
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发表时间：
1997-11-01
期刊：
影响因子：
--
通讯作者：
Nicol, TG
中科院分区：
文献类型：
--
作者：
Sharma, A;Kraus, N;Nicol, TG
中枢听觉系统的正常成熟和功能影响言语感知和口语能力的发展。本研究探讨了听觉诱发电位（AEP）的P1/N1成分的年龄相关变化所反映的中枢听觉通路的成熟。用合成的辅音-元音音节（ba）诱发86名6 ~ 15岁正常儿童和10名正常成人的皮层AEP。成人的反应包括一个突出的负性（N1）在约100毫秒，之前由一个较小的P1组件在约50毫秒。相比之下，儿童的反应的特点是由一个大的P1响应在约100毫秒。该波的潜伏期和振幅显着下降，约20个齿轮的年龄。在儿童中，P1之后是大约200 ms的宽负波，我们称之为N1 b。许多受试者（尤其是年龄较大的儿童）也表现出早期的消极（N1 a）。N1 a和N1 b乳酸均随年龄增长而显著降低。N1 a和N1 b的振幅没有显示出与猿相关的显着变化。所有儿童都有N1 b;然而，N1 a的发生频率随着年龄的增长而增加。数据表明，儿童P1系统地发展成成人反应;然而，N1 a和N1 b与成人N1的关系尚不清楚。这些结果表明，中枢听觉系统的成熟变化是复杂的，并延伸到生命的第二个十年。(C)1997 Elsevier Science爱尔兰有限公司
Normal maturation and functioning of the central auditory system affects the development of speech perception and oral language capabilities. This study examined maturation of central auditory pathways as reflected by age-related changes in the P1/N1 components of the auditory evoked potential (AEP). A synthesized consonant-vowel syllable (ba) was used to elicit cortical AEPs in 86 normal children ranging in age from 6 to 15 years and ten normal adults, Distinct age-related changes were observed in the morphology of the AEP waveform. The adult response consists of a prominent negativity (N1) at about 100 ms, preceded by a smaller P1 component at about 50 ms. In contrast, the child response is characterized by a large P1 response at about 100 ms. This wave decreases significantly in latency and amplitude up to about 20 gears of age. In children, P1 is followed by a broad negativity at about 200 ms which we term N1b. Many subjects (especially older children) also show an earlier negativity (N1a). Both N1a and N1b latencies decrease significantly with age. Amplitudes of N1a and N1b do not show significant ape-related changes. All children have the N1b; however, the frequency of occurrence of N1a increases with age. Data indicate that the child P1 develops systematically into the adult response; however, the relationship of N1a and N1b to the adult N1 is unclear. These results indicate that maturational changes in the central auditory system are complex and extend well into the second decade of life. (C) 1997 Elsevier Science Ireland Ltd.