Socioeconomic status is inversely associated with esophageal squamous cell carcinoma risk: results from a population-based case-control study in China.
Socioeconomic status is inversely associated with esophageal squamous cell carcinoma risk: results from a population-based case-control study in China.
复制标题
社会经济地位与食管鳞状细胞癌风险呈负相关：中国一项基于人群的病例对照研究的结果。
DOI：
10.18632/oncotarget.24003
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发表时间：
2018-01-23
期刊：
影响因子：
--
通讯作者：
Ye W
中科院分区：
文献类型：
--
作者：
Gao P;Yang X;Suo C;Yuan Z;Cheng H;Zhang Y;Jin L;Lu M;Chen X;Ye W
在中国，社会经济地位（SES）被怀疑影响食管鳞状细胞癌（ESCC）的风险，然而，证据仍然不确定，社会经济地位指标的选择仍然不一致。在本研究中，我们在2010年10月至2013年9月期间在中国泰兴进行了一项基于人群的病例对照研究，研究了SES与ESCC风险之间的关系，该研究纳入了1298例组织病理学确诊病例和1900例对照。使用结构化问卷收集社会经济状况指标数据。我们利用多重对应分析（multiple correspondence analysis， MCA）构建了一个基于一系列家用电器拥有量和其他变量的综合财富得分。我们使用无条件逻辑回归来估计ESCC与SES指标相关的95%置信区间（CIs）的比值比（ORs）。在本研究中，SES与ESCC风险呈负相关。高等教育（中学及以上学历vs文盲，or =0.60, 95%CI, 0.41-0.87）、较大的人均住房面积（70平方米vs <45平方米，or =0.71, 95%CI, 0.59-0.86）和较高的财富得分（第5分位数（高）vs第1分位数（低），or =0.43, 95%CI, 0.32-0.57）与ESCC风险降低相关。在50 ~ 50年间拥有多台家用电器的受试者患ESCC的风险也较低。而体力劳动（非常活跃vs久坐，OR=1.69, 95%CI, 1.27-2.26）和大家庭（≥6对<3，OR=1.63, 95%CI, 1.30-2.03）增加了ESCC的风险。这些发现证实了SES与ESCC风险之间的强烈负相关。未来的研究需要验证这些发现，并确定观察到的关联背后的影响因素。
Socioeconomic status (SES) is suspected to influence the risk of esophageal squamous-cell carcinoma (ESCC) in China, however, the evidence is still inconclusive and the selection of SES indicators remains inconsistent. In current study, we examined the association between SES and risk of ESCC based on a population-based case-control study in Taixing, China, with 1298 histopathology-confirmed cases and 1900 controls recruited between October 2010 and September 2013. Data on SES indicators was collected using a structured questionnaire. We constructed a composite wealth score based on the ownership of a series of household appliances and other variables by using multiple correspondence analysis (MCA). We used unconditional logistic regression to estimate odds ratios (ORs) with 95% confidence intervals (CIs) of ESCC in association with SES indicators. SES was inversely associated with ESCC risk in current study. Higher education (secondary high school or above vs illiteracy, OR=0.60, 95%CI, 0.41-0.87), larger house area per person (>70 vs <45 square meters, OR=0.71, 95%CI, 0.59-0.86) and higher wealth score (5th quintile (high) vs 1st quintile (low), OR=0.43, 95%CI, 0.32-0.57) were associated with a decreased risk of ESCC. Subjects possessing several household appliances >5 years also had a lower ESCC risk. Whereas physical labor (very active vs sedentary, OR=1.69, 95%CI, 1.27-2.26) and larger families (≥6 vs <3 in household, OR=1.63, 95%CI, 1.30-2.03) increased the risk of ESCC. These findings confirm the strong inverse association between SES and ESCC risk. Future studies are needed to verify these findings and identify contributing factors underlying the observed associations.