The Measure of Success: Constraints, Objectives, and Tradeoffs in Morphogen-mediated Patterning
The Measure of Success: Constraints, Objectives, and Tradeoffs in Morphogen-mediated Patterning
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DOI：
10.1101/cshperspect.a002022
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发表时间：
2009-07-01
影响因子：
7.2
通讯作者：
Wan, Frederic Y. M.
中科院分区：
文献类型：
--
作者：
Lander, Arthur D.;Lo, Wing-Cheong;Wan, Frederic Y. M.
为了解释形态发生梯度如何达到稳健性和精确性，已经提出了大量的、多样的和越来越多的策略。我们认为，为了发挥作用，对这些策略的评估必须考虑到竞争目标和绩效权衡所施加的约束。这一点是通过对自我增强形态元清除策略的数学和计算分析说明的。结果表明，该策略的有用性与其说来自其增强对形态源波动本身的鲁棒性的能力，不如来自其克服特定类型噪声的能力，并增加形态源梯度的比例，在该梯度中可以建立鲁棒阈值位置。这项工作也为为什么形态发生梯度在体内显示最大范围的长期问题提供了新的见解。
A large, diverse, and growing number of strategies have been proposed to explain how morphogen gradients achieve robustness and precision. We argue that, to be useful, the evaluation of such strategies must take into account the constraints imposed by competing objectives and performance tradeoffs. This point is illustrated through a mathematical and computational analysis of the strategy of self-enhanced morphogen clearance. The results suggest that the usefulness of this strategy comes less from its ability to increase robustness to morphogen source fluctuations per se, than from its ability to overcome specific kinds of noise, and to increase the fraction of a morphogen gradient within which robust threshold positions may be established. This work also provides new insights into the longstanding question of why morphogen gradients show a maximum range in vivo.