Pain insensitivity in the relatives of schizophrenia patients
Pain insensitivity in the relatives of schizophrenia patients
复制标题
DOI：
10.1016/s0920-9964(00)00064-5
复制
发表时间：
2001-03-01
影响因子：
4.5
通讯作者：
Delgado, ML
中科院分区：
文献类型：
--
作者：
Hooley, JM;Delgado, ML
精神病学文献包含关于精神分裂症疼痛敏感度降低的轶事报道，这可以追溯到Kraepelin。然而，精神分裂症患者的疼痛不敏感现象在很大程度上仍未得到研究。例如，尚不清楚疼痛不敏感是疾病的结果，还是精神分裂症患者的亲属也存在这种情况。为了探讨这个问题，我们检查了健康年轻人的痛阈值和疼痛耐受性。与没有精神病理家族史的对照组(n=21)相比，有精神分裂症家族史的参与者(n=32)表现出更高的痛阈值和对手指按压的疼痛耐受性。疼痛不敏感也与自我参照思维、魔法思维和知觉障碍的测量得分升高显著相关。最后，与其他参与者相比，相当大一部分(19%)精神分裂症患者的良好亲属表现出极端的疼痛不敏感。研究结果表明，疼痛不敏感可能值得进一步探索，作为潜在的精神病易感性的标志。(C)2001 Elsevier Science B.V.保留所有权利。
The psychiatric literature contains anecdotal reports of diminished pain sensitivity in schizophrenia that date back to Kraepelin. Yet, the phenomenon of pain insensitivity in schizophrenia remains largely unstudied. For example, it is not clear if pain insensitivity is a consequence of the illness or if it is also present in the well relatives of schizophrenia patients. To explore this issue, we examined pain thresholds and pain tolerances in healthy young adults. Compared with controls with no family history of psychopathology (n = 21), participants with a family history of schizophrenia (n = 32) showed elevated pain thresholds and pain tolerances to finger pressure. Pain insensitivity was also significantly correlated with elevated scores on measures of self-referential thinking, magical ideation, and perceptual disturbances. Finally, a sizeable minority (19%) of well relatives of schizophrenia patients showed extreme pain insensitivity compared to other participants. The pattern of findings suggests that pain insensitivity may warrant further exploration as a potential marker of underlying liability to psychosis. (C) 2001 Elsevier Science B.V. All rights reserved.