Antigen-specific T-T interactions regulate CD4 T-cell expansion
Antigen-specific T-T interactions regulate CD4 T-cell expansion
复制标题
DOI：
10.1182/blood-2007-09-114389
复制
发表时间：
2008-08-15
期刊：
影响因子：
20.3
通讯作者：
Lantz, Olivier
中科院分区：
文献类型：
--
作者：
Helft, Julie;Jacquet, Alexandra;Lantz, Olivier
在免疫应答过程中对CD4 T细胞数量的调节应考虑抗原（Ag）的数量、Ag特异性T细胞的初始频率、初始细胞与经验细胞的混合，以及（理想情况下）库的多样性。在这里，我们描述了一种新的t细胞调节机制，它可能处理所有这些参数。我们发现CD4 T细胞通过从ag呈递细胞中捕获其同源的主要组织相容性类(MHC)/肽复合物，并将其呈递到ag经历的CD4 T细胞中，从而抑制它们进入应答，同时允许幼稚T细胞的募集，从而建立了一个负反馈回路。这种抑制是银特异性的，从第2天开始（早在银消失之前），不能通过提供新的载银树突状细胞来克服。通过这种方式，CD4 T细胞增殖在与Ag数量的功能关系中受到调节，同时允许幼稚T细胞产生各种各样的库。
The regulation of CD4 T-cell numbers during an immune response should take account of the amount of antigen (Ag), the initial frequency of Ag-specific T cells, the mix of naive versus experienced cells, and (ideally) the diversity of the repertoire. Here we describe a novel Mechanism of T-cell regulation that potentially deals with all of these parameters. We found that CD4 T cells establish a negative feedback loop by capturing their cognate major histocompatibility class (MHC)/peptide complexes from Ag-presenting cells and presenting them to Ag-experienced CD4 T cells, thereby inhibiting their recruitment into the response while allowing recruitment of naive T cells. The inhibition is Ag specific, begins at day 2 (long before Ag disappearance), and cannot be overcome by providing new Ag-loaded dendritic cells. In this way, CD4 T-cell proliferation is regulated in a functional relationship to the amount of Ag, while allowing naive T cells to generate repertoire variety.