CIGARETTE-SMOKING AND URINARY ESTROGENS
CIGARETTE-SMOKING AND URINARY ESTROGENS
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DOI：
10.1056/nejm198210213071707
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发表时间：
1982-01-01
影响因子：
158.5
通讯作者：
BROWN, J
中科院分区：
文献类型：
--
作者：
MACMAHON, B;TRICHOPOULOS, D;BROWN, J
众所周知，吸烟的女性比不吸烟的女性更年期更早。1，2最近的数据表明，吸烟者患乳腺癌的几率可能比不吸烟者低。345我们认为，比较吸烟者和不吸烟者的雌激素谱是值得的。这一差异可能会揭示吸烟与更年期提前和乳腺癌风险降低相关的机制。吸烟史是从之前已测定过尿雌激素浓度的女性那里获得的。与不吸烟者和戒烟者相比，吸烟者的死亡率显著和显著降低。
IT is known that women who smoke have an earlier menopause than those who do not.1,2Noting recent data suggesting that breast cancer might be somewhat less frequent in smokers than in non-smokers,345we thought it would be worthwhile to compare the estrogen profiles of smokers and nonsmokers. A difference might shed light on the mechanisms whereby smoking is associated with early menopause and with a reduction in the risk of breast cancer. Smoking histories were obtained from women for whom urinary estrogen concentrations had been determined previously. As compared with nonsmokers and exsmokers, smokers had substantially and significantly lower . . .