Ultrasonic tissue characterization of atherosclerosis by a speed-of-sound microscanning system
Ultrasonic tissue characterization of atherosclerosis by a speed-of-sound microscanning system
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DOI：
10.1109/tuffc.2007.427
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发表时间：
2007-08-01
影响因子：
3.6
通讯作者：
Okada, Nagaya
中科院分区：
文献类型：
--
作者：
Saijo, Yoshifumi;Santos Filho, Esmeraldo;Okada, Nagaya
我们一直在开发一种用于医学和生物学的扫描声学显微镜（SAM）系统，该系统具有定量测量软组织超声参数的功能。在本研究中，我们提出了一种新的概念声速显微镜，它可以使用单个脉冲波的快速傅立叶变换来测量组织中的声速和厚度，而不是传统的SAM系统中使用的爆发波。冷冻两根冠状动脉，切片厚度约10 μ m。它们被安装在没有盖片的玻璃片上。300 × 300像素帧的扫描时间为90 s，得到声速的二维分布。在胶原纤维增厚的内膜中声速为1680 30m /s，在纤维帽下的脂质沉积中声速为1520 8m /s，在内膜钙化病变中声速为1810 25m /s。这些基本测量将有助于理解血管内超声图像的回波强度和模式。
We have been developing a scanning acoustic microscope (SAM) system for medicine and biology featuring quantitative measurement of ultrasonic parameters of soft tissues. In the present study, we propose a new concept sound speed microscopy that can measure the thickness and speed of sound in the tissue using fast Fourier transform of a single pulsed wave instead of burst waves used in conventional SAM systems. Two coronary arteries were frozen and sectioned approximately 10 mu m in thickness. They were mounted on glass slides without cover slips. The scanning time of a frame with 300 x 300 pixels was 90 s and two-dimensional distribution of speed of sound was obtained. The speed of sound was 1680 30 m/s in the thickened intima with collagen fiber, 1520 8 m/s in the lipid deposition underlying the fibrous cap, and 1810 25 m/s in a calcified lesion in the intima. These basic measurements will help in the understanding of echo intensity and pattern in intravascular ultrasound images.