TOBACCO, ALCOHOL INTAKE, AND DIET IN RELATION TO ADENOCARCINOMA OF THE ESOPHAGUS AND GASTRIC CARDIA
TOBACCO, ALCOHOL INTAKE, AND DIET IN RELATION TO ADENOCARCINOMA OF THE ESOPHAGUS AND GASTRIC CARDIA
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DOI：
10.1007/bf00053153
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发表时间：
1993-03-01
影响因子：
2.3
通讯作者：
WYNDER, EL
中科院分区：
文献类型：
--
作者：
KABAT, GC;NG, SKC;WYNDER, EL
关于远端食道/贲门腺癌的病因知之甚少，在过去的二十年中，这种癌症在美国的发病率有所增加。我们分析了173例患有远端食管/贲门腺癌的住院男性患者（病例）和4,544例患有与吸烟无关的其他器官系统疾病的住院男性患者（对照组）的吸烟、饮酒、饮食摄入和其他因素的数据。食管鳞状细胞癌（n = 136）和胃远端腺癌（n = 122）作为单独的病例组。所有研究对象于1981年至1990年间在美国8个城市的28家医院接受了采访。调整协变量后，当前吸烟者患食管/贲门远端腺癌的比值比（OR）为2.3(95%可信区间[CI] = 1.4-3.9)，而前吸烟者相对于不吸烟者的比值比为1.9 （CI = 1.2-3.0）。每天饮用四盎司或更多威士忌（相当于酒精）的饮酒者（相对于每周喝不到一杯的人）的OR为2.3 （CI = 1.3-4.3）。动物来源的总脂肪和维生素A摄入量是显著的危险因素，纤维摄入量与食管/贲门远端腺癌呈负相关。虽然女性远端食道/贲门腺癌的病例数很少（n = 21），但吸烟和饮酒之间存在显著关联。
Little is known about the etiology of adenocarcinoma of the distal esophagus/cardia, a cancer which has increased in incidence in the United States over the last two decades. We analyzed data on smoking, alcohol use, dietary intake, and other factors obtained from 173 hospitalized males with adenocarcinoma of the distal esophagus/cardia (cases) and 4,544 hospitalized males with diseases not related to smoking and of other organ systems than the gastrointestinal tract (controls). Cases of squamous cell carcinoma of the esophagus (n = 136) and adenocarcinoma of the distal stomach (n = 122) were included as separate case groups. All subjects were interviewed in 28 hospitals in eight cities in the US between 1981 and 1990. After adjustment for covariates, the odds ratio (OR) for adenocarcinoma of the distal esophagus/cardia for current smokers was 2.3 (95 percent confidence interval [CI] = 1.4-3.9) and that for ex-smokers was 1.9 (CI = 1.2-3.0) relative to never-smokers. The OR for drinkers of four or more ounces of whiskey-equivalents of alcohol per day (relative to those consuming less than one drink per week) was 2.3 (CI = 1.3-4.3). Intakes of total fat and vitamin A from animal sources were significant risk factors and fiber intake was associated inversely with adenocarcinoma of the distal esophagus/cardia. Although the number of female cases of adenocarcinoma of the distal esophagus/cardia was small (n = 21), significant associations were observed for smoking and alcohol.