Noradrenaline binding and the search for catecholamine receptors
Noradrenaline binding and the search for catecholamine receptors
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去甲肾上腺素结合和儿茶酚胺受体的寻找
作者：
P. Cuatrecasas;G. Tell;V. Sica;I. Parikh;Kwen
3 H-去甲肾上腺素与完整细胞和微粒体的结合似乎不能测量儿茶酚胺受体的相互作用，而是一种可能与儿茶酚-O-甲基转移酶相关的膜儿茶酚结合蛋白。真正的受体可能是稀缺的，检测将需要比目前可用的高得多的比活性的儿茶酚胺衍生物。
The binding of 3H-noradrenaline to intact cells and microsomes seems not to measure catecholamine receptor interactions, but rather a membrane catechol-binding protein which may be related to the enzyme, catechol-O-methyl transferase. True receptors are probably scarce and detection will require catecholamine derivatives of much higher specific activity than are at present available.