Moderately decreased renal function negatively affects the health-related quality of life among the elderly Korean population: a population-based study
Moderately decreased renal function negatively affects the health-related quality of life among the elderly Korean population: a population-based study
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DOI：
10.1093/ndt/gfn132
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发表时间：
2008-09-01
影响因子：
6.1
通讯作者：
Chae, Dong-Wan
中科院分区：
文献类型：
--
作者：
Chin, Ho Jun;Song, Young Rim;Chae, Dong-Wan
背景在韩国，慢性肾脏病（CKD）的发病率正在增加，尤其是在老年人群中。慢性肾功能不全患者的健康相关生活质量（HRQOL）低于一般人群，较低的HRQOL是不良事件的预测因子。我们报告了生活在韩国某城市的老年人群肾功能对HRQOL的影响以及HRQOL差的危险因素。本研究作为韩国健康与老龄化纵向研究（KLoSHA）的一部分进行，该研究设计为一项基于人群的前瞻性队列研究，研究对象为居住在韩国卫星城市首尔的年龄> 65岁的人群。在随机选择的1 000名受试者中，944名能够完成SF-36问卷以测量HRQOL。我们将参与者分为五组：第1组：90 mL/min/1.73 m（2）或更高，第2组：89-75 mL/min/1.73 m（2），第3组：60-74 mL/min/1.73 m（2），第4组：45-59 mL/min/1.73 m（2）和第5组：小于45 mL/min/1.73 m（2）。除一般健康感知和心理健康量表外，SF-36量表的所有其他评分均显示根据GFR分类的五组之间存在差异。然而，与其他四个GFR组相比，只有GFR值< 45 mL/min/1.73 m（2）的参与者的评分显著降低。校正后，GFR值< 45 mL/min/1.73 m（2）的受试者的身体成分总评分最低。以45 mL/min/1.73 m2为标准的二分GFR因子是身体HRQOL差的独立预测因子。其他因素，如年龄，性别，受教育年限，经常锻炼的习惯，抑郁和心血管意外史，也是HRQOL的预测因子。较低的血红蛋白水平与心理成分总结有关。肾功能被认为是HRQOL的重要预测因子，即使在老年组也是如此。肾功能中度下降45 mL/min/1.73 m（2）GFR是韩国老年人群HRQOL下降的水平。
Background. The incidence of chronic kidney disease (CKD) is increasing in Korea, especially in the aged population. The health-related quality of life (HRQOL) of patients with chronic renal insufficiency is lower than that for the general population and a lower HRQOL is a predictor of adverse events. We report the impact of kidney function on the HRQOL and the risk factors for poor HRQOL in an elderly population living in one Korean city.Methods. This study was conducted as a part of the Korean Longitudinal Study on Health and Aging (KLoSHA) that was designed as a population-based, prospective cohort-study in a population aged > 65 years living in a satellite city of Seoul in Korea. Among 1 000 randomly selected subjects, 944 were able to complete the SF-36 questionnaires to measure HRQOL. We categorized the participants into five GFR groups: group 1: 90 mL/min/1.73 m(2) or more, group 2: 89-75 mL/min/1.73 m(2), group 3: 60-74 mL/min/1.73 m(2), group 4: 45-59 mL/min/1.73 m(2) and group 5: less than 45 mL/min/1.73 m(2).Results. Except for the general health perception and mental health scale, all the other scores of the SF-36 scales showed differences among five groups categorized according to GFR. However, the scores were significantly decreased only among participants with a GFR value of < 45 mL/min/1.73 m(2), compared to the other four GFR groups. After adjustment, the physical component summary score was the lowest in participants with GFR values < 45 mL/min/1.73 m(2). The dichotomized GFR factor with the criterion of 45 mL/min/1.73 m(2) was an independent predictor of poor physical HRQOL. Other factors, such as age, gender, duration of education, regular exercising habits, depression and a history of cardiovascular accident, were also predictors of HRQOL. A lower haemoglobin level was related to the mental component summary.Conclusion. The renal function deduced to be an important predictor of HRQOL, even in the old age group. The moderately decreased renal function of 45 mL/min/1.73 m(2) GFR was the level at which HRQOL decreased in the elderly Korean population.