Abnormal response to exercise, face immersion, and isoproterenol in children with the long QT syndrome
Abnormal response to exercise, face immersion, and isoproterenol in children with the long QT syndrome
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DOI：
10.1111/j.1540-8159.1995.tb04637.x
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发表时间：
1995-12-01
影响因子：
1.8
通讯作者：
Orii, T
中科院分区：
文献类型：
--
作者：
KatagiriKawade, M;Ohe, T;Orii, T
本研究旨在观察长QT综合征（LQTS）患者交感神经刺激引起的QT间期变化。研究组由 6 名患有 LQTS 的儿童和 6 名无 QT 延长的健康儿童组成。所有 LQTS 患者均出现晕厥发作。通过跑步机测试、面部浸泡和异丙肾上腺素检查 QT(c) 和 Delta QT(c)%（[检查后 QT(c) 间期 - 休息时 QT(c) 间期]/休息时 QT(c) 间期 X 200）。跑步机测试峰值运动后一分钟，两组 QT(c) 间期变化均不显着，但 LQTS 组的 Delta QT(c)% 大于对照组（+11.0 +/- 12.1% vs -2.6 +/- 3.2 %；P = 0.02）。面部浸泡期间最短RR间期的QT(c)间期在LQTS组中延长（0.47+/-0.01s至0.51+/-0.04s；P=0.02），但对照组没有显着变化（0.40+/-0.03s至0.41+/-0.03s；P=NS）。 LQTS 组的 Delta QT(c)% 大于对照组（+10.0 +/- 7.3% vs +1.1 +/- 5.5%；P = 0.04）。在LQTS组中，输注异丙肾上腺素后RR间期缩短（P = 0.009），QT（c）间期延长（P = 0.0008）。这些交感神经刺激放大了 LQTS 组的 TU 异常。通过观察人脸浸泡引起的TU变化，我们希望找到一种可能的新方法来诊断LQTS。这些检查的结合可能有助于筛查 TU 异常的边缘病例。
The present study was performed to observe the change of QT interval by sympathetic stimulations in patients with the long QT syndrome (LQTS). The study group consisted of 6 children with LQTS and 6 healthy children without QT prolongation. All LQTS patients had syncopal episodes. The QT(c) and Delta QT(c)% ([QT(c) interval after examination - QT(c) interval at rest]/QT(c) interval at rest X 200) by treadmill testing, face immersion, and isoproterenol were examined. One minute after peak exercise of treadmill testing, the changes in the QT(c) interval were not significant in either group, but Delta QT(c)% was larger in the LQTS group than in the control group (+11.0 +/- 12.1% vs -2.6 +/- 3.2 %; P = 0.02). The QT(c) interval at the shortest RR interval during face immersion was prolonged in the LQTS group (0.47 +/- 0.01 s to 0.51 +/- 0.04 s; P = 0.02), but there were no significant changes in the control group (0.40 +/- 0.03 s to 0.41 +/- 0.03 s; P = NS). Delta QT(c)% was larger in the LQTS group than in the control group (+10.0 +/- 7.3% vs +1.1 +/- 5.5%; P = 0.04). In the LQTS group, the RR interval was shortened (P = 0.009) and QT(c) interval was prolonged (P = 0.0008) after isoproterenol infusion. These sympathetic stimulations amplified the TU abnormality in the LQTS group. By observing the TU changes caused by face immersion, we hoped to find a possible new method with which to diagnose LQTS. The combination of these examinations may be helpful in screening the borderline cases of TU abnormalities.