The role and diagnostic significance of cellular barriers after concussive head trauma.
The role and diagnostic significance of cellular barriers after concussive head trauma.
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DOI：
10.2217/cnc-2017-0019
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发表时间：
2018-03-01
期刊：
影响因子：
--
通讯作者：
Janigro, Damir
中科院分区：
文献类型：
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作者：
Dadas, Aaron;Janigro, Damir
脑震荡性脑外伤的发生往往会引发一系列复杂的生理后果和病理生理反应。这些后遗症可以是急性的（即，血肿）或慢性（即，自身免疫反应、神经变性等），并且可能在任何严重程度的创伤之后。确定脑震荡后结果的一个关键因素是细胞屏障的病理生理反应，这可以通过急性和慢性损伤后阶段的几种生物标志物来测量。我们在此提出了一个审查后脑震荡机制的血脑屏障，以及诊断/预后的方法，利用差异生物标志物的表达跨越这一边界。我们讨论了血-唾液细胞屏障作为血液中脑源性生物标志物的调节过滤器的作用，及其对唾液诊断测定的影响。
The onset of concussive head trauma often triggers an intricate sequence of physical consequences and pathophysiological responses. These sequelae can be acute (i.e., hematoma) or chronic (i.e., autoimmune response, neurodegeneration, etc.), and may follow traumas of any severity. A critical factor for prognostication of postconcussion outcome is the pathophysiological response of cellular barriers, which can be measured by several biomarkers of the acute and chronic postinjury phases. We present herein a review on the postconcussion mechanisms of the blood-brain barrier, as well as the diagnostic/prognostic approaches that utilize differential biomarker expression across this boundary. We discuss the role of the blood-saliva cellular barrier as a regulatory filter for brain-derived biomarkers in blood, and its implications for saliva-based diagnostic assays.