Intestinal somatostatin function.
Intestinal somatostatin function.
复制标题
肠道生长抑素功能。
DOI：
10.1007/978-1-4615-7886-4_25
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发表时间：
1985
影响因子：
--
通讯作者：
Dharmsathaphorn,K
中科院分区：
文献类型：
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作者：
Dharmsathaphorn,K
生长抑素存在于整个肠道，既存在于肠腔表面的D细胞中，也存在于神经细胞中。它抑制许多已知调节胃肠功能的肠道激素的释放或作用，无疑具有广泛的作用。在肠道中，现有信息表明生长抑素可能对水和电解质的吸收和分泌具有重要的调节作用。该肽既影响上皮转运功能，又影响肠蠕动功能。与施用生长抑素相关的结果是抑制水和电解质的分泌。生长抑素已被证明可以有效地减少与内分泌肿瘤和其他疾病相关的腹泻综合征的粪便排出量。生长抑素在腹泻中的临床应用仍有待开发一种口服活性和/或肠道特异性类似物。一些初步结果表明，这在未来是可能的。
Somatostatin is present throughout the intestine, both in D cells at the luminal surface and in neural elements. It inhibits the release or action of many gut hormones known to regulate gastrointestinal function and undoubtedly has a wide range of actions. In the intestine, available information indicates that somatostatin may have an important regulatory role for water and electrolyte absorption and secretion. The peptide affects both the epithelial transport function and the intestinal motility function. The outcome associated with administration of somatostatin is inhibition of water and electrolyte secretion. Somatostatin has been shown to effectively reduce stool output in diarrheal syndromes associated with endocrine tumor and other conditions. Clinical application of somatostatin in diarrhea still awaits development of an orally active and/or gut-specific analog. Some preliminary results indicate that this may be possible in the future.