Cytological features of stromal spindle cells and their prognostic significance in lung adenocarcinoma
Cytological features of stromal spindle cells and their prognostic significance in lung adenocarcinoma
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DOI：
10.1111/cyt.13232
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发表时间：
2023-03
期刊：
影响因子：
1.3
通讯作者：
Kana Miyata-Morita;S. Morita;H. Dejima;Koji Saito;Y. Sakao;M. Mochizuki;Y. Sasajima
中科院分区：
文献类型：
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作者：
Kana Miyata-Morita;S. Morita;H. Dejima;Koji Saito;Y. Sakao;M. Mochizuki;Y. Sasajima
肿瘤微环境中的肿瘤相关成纤维细胞(CAF)在肿瘤的发生、增殖、侵袭和转移中起着关键作用。梭形细胞的细胞学特征包括CAF-定义为与癌细胞相邻的间质梭形细胞(SSCs)-在肺腺癌中经常遇到。本研究旨在探讨SSCs在细胞学标本中的存在与临床病理特征之间的关系。
Cancer‐associated fibroblasts (CAFs) in the tumour microenvironment play a key role in tumour development, proliferation, invasion, and metastasis. The cytological features of spindle cells including CAFs—defined as stromal spindle cells (SSCs) adjacent to cancer cells—are frequently encountered in pulmonary adenocarcinomas. This study aimed to investigate the association between the presence of SSCs in cytological specimens and the clinicopathological features.