Heat shock protein family A member 6 combined with clinical characteristics for the differential diagnosis of intestinal Behcet's disease
Heat shock protein family A member 6 combined with clinical characteristics for the differential diagnosis of intestinal Behcet's disease
复制标题
热休克蛋白A家族成员6结合临床特征对肠道白塞病的鉴别诊断
DOI：
10.1111/1751-2980.12613
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发表时间：
2018-06-01
影响因子：
3.5
通讯作者：
Chen, Min Hu
中科院分区：
文献类型：
--
作者：
Feng, Rui;Chao, Kang;Chen, Min Hu
目的探讨热休克蛋白家族A成员6 （HSPA6）单独表达及结合临床特征在区分肠白塞病（BD）与克罗恩病（CD）累及回肠结肠中的作用。方法入选诊断为肠道BD或CD的患者。回顾性分析两例患者的临床特点、疾病活动性、超敏c反应蛋白（hsCRP）和红细胞沉降率（ESR）等实验室检查结果、内镜、病理和放射学特征。采用酶联免疫吸附法测定血清HSPA6水平。结果肠道BD患者以腹痛和腹泻为主要胃肠道症状。粘膜下淋巴细胞浸润是最常见的病理表现。计算机断层肠摄影表现为节段数小于4节段，肠壁增厚。小肠BD与CD鉴别诊断的独立因素为圆形/椭球型肠溃疡(P13mm （P3.725 ng/mL (P = 0.008)）。与CD （0.50 +/- 0.24ng/mL， P=0.000）和健康对照组（0.38 +/- 0.37ng/mL， P=0.000）相比，小肠BD患者血清HSPA6表达（0.720.39ng/mL）显著升高。结论hspa6结合临床、影像学和病理特征可用于区分肠内BD和累及回肠结肠的CD。
OBJECTIVETo investigate the role of heat shock protein family A member 6 (HSPA6) expression alone and in combination with clinical characteristics in distinguishing intestinal Behcet's disease (BD) from Crohn's disease (CD) with ileocolonic involvement.METHODSPatients diagnosed with either intestinal BD or CD were enrolled. Their clinical characteristics, disease activity, laboratory test results including hypersensitive C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR), endoscopic, pathological and radiological features were retrospectively analyzed. Enzyme-linked immunosorbent assay was applied to measure serum HSPA6 levels.RESULTSAmong intestinal BD patients, abdominal pain and diarrhea were the leading gastrointestinal symptoms. Submucosal lymphocyte infiltration was the most common pathological finding. Computed tomography enterography features involved number of segments of less than 4 and bowel wall thickening. Independent factors were round/ellipsoid intestinal ulcer (P13mm (P3.725 ng/mL (P = 0.008) for the differential diagnosis between intestinal BD and CD. Serum HSPA6 expression was significantly elevated in intestinal BD (0.720.39ng/mL) compared with CD (0.50 +/- 0.24ng/mL, P=0.000) and healthy controls (0.38 +/- 0.37ng/mL, P=0.000).CONCLUSIONHSPA6 in combination with clinical, radiological and pathological characteristics is useful in distinguishing intestinal BD from CD with ileocolonic involvement.