Validation of the colour difference plot scoring system analysis of the 103 hexagon multifocal electroretinogram in the evaluation of hydroxychloroquine retinal toxicity.
Validation of the colour difference plot scoring system analysis of the 103 hexagon multifocal electroretinogram in the evaluation of hydroxychloroquine retinal toxicity.
复制标题
103六边形多焦视网膜电图色差图评分系统分析在评估羟氯喹视网膜毒性中的验证。
DOI：
10.1111/aos.12353
复制
发表时间：
2014
影响因子：
3.4
通讯作者：
Han,DennisP
中科院分区：
文献类型：
--
作者：
Graves,GabrielleS;Adam,MurtazaK;Stepien,KimberlyE;Han,DennisP
PurposeTo evaluate sensitivity, specificity and reproducibility of colour difference plot analysis (CDPA) of 103 hexagon multifocal electroretinogram (mfERG) in detecting established hydroxychloroquine (HCQ) retinal toxicity.MethodsTwenty‐three patients taking HCQ were divided into those with and without retinal toxicity and were compared with a control group without retinal disease and not taking HCQ. CDPA with two masked examiners was performed using age‐corrected mfERG responses in the central ring (Rc; 0–5.5 degrees from fixation) and paracentral ring (Rp; 5.5–11 degrees from fixation). An abnormal ring was defined as containing any hexagons with a difference in two or more standard deviations from normal (colour blue or black).ResultsCategorical analysis (ring involvement or not) showedRchad 83% sensitivity and 93% specificity.Rphad 89% sensitivity and 82% specificity. Requiring abnormal hexagons in bothRcandRpyielded sensitivity and specificity of 83% and 95%, respectively. If required in only one ring, they were 89% and 80%, respectively. In this population, there was complete agreement in identifying toxicity when comparing CDPA usingRpwith ring ratio analysis using R5/R4 P1ring responses (89% sensitivity and 95% specificity). Continuous analysis of CDPA with receiver operating characteristic analysis showed optimized detection (83% sensitivity and 96% specificity) when ≥4 abnormal hexagons were present anywhere within theRpring outline. Intergrader agreement and reproducibility were good.ConclusionsColour difference plot analysis had sensitivity and specificity that approached that of ring ratio analysis of R5/R4 P1responses. Ease of implementation and reproducibility are notable advantages of CDPA.
