Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy.
Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy.
复制标题
用于多重成像引导组合癌症治疗的可生物降解核壳双金属有机框架纳米治疗剂
作者：
Wang D;Zhou J;Shi R;Wu H;Chen R;Duan B;Xia G;Xu P;Wang H;Zhou S;Wang C;Wang H;Guo Z;Chen Q
金属有机骨架（MOFs）具有高孔隙率、大表面积和可调节的功能性，是用于癌症治疗中的同步诊断和治疗的有希望的候选者。尽管已经发现了大量的MOF，但是传统的基于MOF的纳米平台主要限于具有唯一功能的唯一MOF源。在这项研究中，表面活性剂改性的普鲁士蓝（PB）核包覆紧凑的ZIF-8壳（核-壳双MOFs，CSD-MOFs）已报告通过一个通用的逐步的方法。以普鲁士蓝为核心，CSD-MOFs能够用作磁共振成像（MRI）和荧光光学成像（FOI）试剂。我们表明，CSD-MOFs晶体负载抗癌药物阿霉素（DOX）是有效的pH和近红外（NIR）双刺激响应的药物递送载体。在ZIF-8降解后，对内部PB M0 F的同时NIR照射持续产生杀死癌细胞的热量。它们对HeLa癌细胞系的疗效高于各自的单一治疗方式，实现了协同化疗-热疗法的疗效。体内实验结果表明，CSD-MOFs@DOX+NIR的抗肿瘤功效分别是单一化疗和单一热疗的7.16倍和5.07倍。我们的策略开辟了新的可能性，通过整合两种不同的MOF构建多功能治疗诊断系统。
Metal-organic-frameworks (MOFs) possess high porosity, large surface area, and tunable functionality are promising candidates for synchronous diagnosis and therapy in cancer treatment. Although large number of MOFs has been discovered, conventional MOF-based nanoplatforms are mainly limited to the sole MOF source with sole functionality. In this study, surfactant modified Prussian blue (PB) core coated by compact ZIF-8 shell (core-shell dual-MOFs, CSD-MOFs) has been reported through a versatile stepwise approach. With Prussian blue as core, CSD-MOFs are able to serve as both magnetic resonance imaging (MRI) and fluorescence optical imaging (FOI) agents. We show that CSD-MOFs crystals loading the anticancer drug doxorubicin (DOX) are efficient pH and near-infrared (NIR) dual-stimuli responsive drug delivery vehicles. After the degradation of ZIF-8, simultaneous NIR irradiation to the inner PB MOFs continuously generate heat that kill cancer cells. Their efficacy on HeLa cancer cell lines is higher compared with the respective single treatment modality, achieving synergistic chemo-thermal therapy efficacy. In vivo results indicate that the anti-tumor efficacy of CSD-MOFs@DOX+NIR was 7.16 and 5.07 times enhanced compared to single chemo-therapy and single thermal-therapy respectively. Our strategy opens new possibilities to construct multifunctional theranostic systems through integration of two different MOFs.