Effects of compression on soft tissue optical properties
Effects of compression on soft tissue optical properties
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DOI：
10.1109/2944.577320
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发表时间：
1996-12-01
影响因子：
4.9
通讯作者：
Welch, AJ
中科院分区：
文献类型：
--
作者：
Chan, EK;Sorg, B;Welch, AJ
组织光学性质是光医学中规定的光剂量学所必需的参数，在许多使用光纤探头的诊断或治疗应用中，经常对组织施加压力以减少折射率失配和增加光透过率。在本文中，我们用可见光-红外光谱仪测量了体外光学性质随压力的变化。所有测量都使用400-1800 nm的光谱范围，光谱分辨率为5 nm，从组织库、牛主动脉和巩膜获得一名西班牙裔供体和两名高加索供体的皮肤样本，从当地屠宰场获得猪巩膜，每个样本夹在显微镜载玻片之间，用弹簧加载装置压缩，然后在空载情况下测量每个样本的漫反射和透射率，在大约0.1、1和2kgf/cm(2)的情况下，压缩下组织厚度减少78%，一般说来，压缩下反射率降低而总透射率增加。用反相加倍法计算了压缩试件的吸收系数和折合散射系数，与空载对照相比，大多数压缩试件的吸收系数和散射系数都有所增加。
Tissue optical properties are necessary parameters for prescribing light dosimetry in photomedicine, In many diagnostic or therapeutic applications where optical fiber probes are used, pressure is often applied to the tissue to reduce index mismatch and increase light transmittance, In this paper, we have measured in vitro optical properties as a function of pressure with a visible-IR spectrophotometer. A spectral range of 400-1800 nm with a spectral resolution of 5 nm was used for all measurements, Skin specimens of a Hispanic donor and two Caucasian donors were obtained from the tissue bank, Bovine aorta and sclera, and porcine sclera came from a local slaughter house, Each specimen, sandwiched between microscope slides, was compressed by a spring-loaded apparatus, Then diffuse reflectance and transmittance of each sample were measured at no load and at approximately 0.1, 1, and 2 kgf/cm(2), Under compression, tissue thicknesses were reduced up to 78%, Generally speaking, the reflectance decreased while the overall transmittance increased under compression, The absorption and reduced scattering coefficients were calculated using the inverse adding doubling method, Compared with the no-load controls, there was an increase in absorption and scattering coefficients among most of the compressed specimens.