Lung cancer and prior tuberculosis infection in Shanghai.
Lung cancer and prior tuberculosis infection in Shanghai.
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上海的肺癌和先前的结核病感染。
DOI：
10.1038/bjc.1987.233
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发表时间：
1987-10
影响因子：
8.8
通讯作者：
Gao YT
中科院分区：
文献类型：
--
作者：
Zheng W;Blot WJ;Liao ML;Wang ZX;Levin LI;Zhao JJ;Fraumeni JF Jr;Gao YT
在一项以人群为基础的肺癌病例对照研究中，在1984-86年期间，对1405名癌症患者和1495名对照者进行了访谈，观察到在有结核病史的人群中，肺癌风险显著升高50%（经吸烟调整）。在过去20年内被诊断为结核病的人中，风险超过2.5倍。在男性中，肺癌往往发生在与既往结核感染的同一侧。对于两性而言，近期结核对腺癌和周围肿瘤的影响最为明显。没有发现肺癌风险与结核病治疗类型之间的关系，包括异烟肼的使用。研究结果表明，结核病可能易患肺癌，这种关联在最近感染的幸存者中最为明显。
In a population-based case-control study of lung cancer in Shanghai involving interviews during 1984-86 with 1,405 cancer patients and 1,495 controls, a significant 50% elevation in the risk of lung cancer, adjusted for cigarette smoking, was observed among persons who had a history of tuberculosis. Among those diagnosed with tuberculosis within the past 20 years, the risk exceeded 2.5-fold. In males the lung cancers tended to occur on the same side as the previous tuberculosis infection. For both sexes, the effect of recent tuberculosis was most apparent for adenocarcinoma and peripheral tumours. No relationship was found between lung cancer risk and the type of tuberculosis therapy, including use of isoniazid. The findings suggest that tuberculosis may predispose to lung cancer, with the association most apparent among recent survivors of the infection.