DNA damage responses in cancer stem cells: Implications for cancer therapeutic strategies.
DNA damage responses in cancer stem cells: Implications for cancer therapeutic strategies.
复制标题
DOI：
10.4331/wjbc.v6.i3.57
复制
发表时间：
2015-08-26
期刊：
影响因子：
--
通讯作者：
Wang, Qi-En
中科院分区：
文献类型：
--
作者：
Wang, Qi-En
肿瘤干细胞（cancer stem cells，CSCs）是肿瘤发生、生长、转移和耐药的重要细胞，对肿瘤的治疗有着重要的意义。与干细胞类似，CSC也显示出对遗传毒性剂的放疗和化疗的高抗性。因此，常规治疗可以缩小肿瘤体积，但不能消除癌症。肿瘤干细胞的放射治疗是一种新的治疗策略。CSC具有高效的DNA损伤反应（DDR）系统，其被认为是这些细胞抵抗暴露于DNA损伤剂的贡献者。因此，提出了靶向CSC中增强的DDR以促进通过常规疗法根除CSC。为了实现这一目标，需要更好地了解CSC中DNA损伤的细胞反应。除了参与DDR的蛋白激酶和酶之外，还应该探索影响DDR的其他过程，包括染色质重塑。
The identification of cancer stem cells (CSCs) that are responsible for tumor initiation, growth, metastasis, and therapeutic resistance might lead to a new thinking on cancer treatments. Similar to stem cells, CSCs also display high resistance to radiotherapy and chemotherapy with genotoxic agents. Thus, conventional therapy may shrink the tumor volume but cannot eliminate cancer. Eradiation of CSCs represents a novel therapeutic strategy. CSCs possess a highly efficient DNA damage response (DDR) system, which is considered as a contributor to the resistance of these cells from exposures to DNA damaging agents. Targeting of enhanced DDR in CSCs is thus proposed to facilitate the eradication of CSCs by conventional therapeutics. To achieve this aim, a better understanding of the cellular responses to DNA damage in CSCs is needed. In addition to the protein kinases and enzymes that are involved in DDR, other processes that affect the DDR including chromatin remodeling should also be explored.