Severe acute interstitial nephritis induced by valsartan: A case report
Severe acute interstitial nephritis induced by valsartan: A case report
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缬沙坦致重症急性间质性肾炎一例
DOI：
10.1097/md.0000000000014428
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发表时间：
2019
期刊：
影响因子：
1.6
通讯作者：
Shang Wen ya
中科院分区：
文献类型：
--
作者：
Chen Tong;Xu Peng cheng;Hu Shui yi;Yan Tie kun;Jiang Jian Qing;Jia Jun ya;Wei Li;Shang Wen ya
干预措施：给予糖皮质激素治疗。结果：血肌酐逐渐下降，5个月后恢复正常。随后停止糖皮质激素治疗。经CT血管造影（CTA）排除肾动脉狭窄。教训：虽然缬沙坦引起的过敏已有报道，但AIN是首次被认为是该药的严重并发症。我们建议，对于无肾功能不全、肾动脉狭窄、心力衰竭或低血容量的患者，当出现ARB相关的肾功能持续恶化时，应考虑AIN，必要时应考虑糖皮质激素治疗。
Interventions:The patient was treated with glucocorticoid.Outcomes:The serum creatinine decreased gradually and got back to normal level 5 months later. Then therapy of glucocorticoid was stopped. Renal artery stenosis was excluded by computed tomography angiography (CTA).Lessons:Although valsartan-induced allergy has been reported previously, AIN was firstly recognized as a severe complication of this drug. We suggest when there is a ARB-associated continuous deterioration of kidney function for patients without renal insufficiency, renal artery stenosis, heart failure or hypovolemia, AIN should be thought of and therapy with glucocorticoid should be considered if necessary.