ISOLATION OF DROSOPHILA GENES ENCODING G-PROTEIN-COUPLED RECEPTOR KINASES
ISOLATION OF DROSOPHILA GENES ENCODING G-PROTEIN-COUPLED RECEPTOR KINASES
复制标题
DOI：
10.1073/pnas.88.24.11067
复制
发表时间：
1991-12-01
影响因子：
11.1
通讯作者：
ZUKER, CS
中科院分区：
文献类型：
--
作者：
CASSILL, JA;WHITNEY, M;ZUKER, CS
G蛋白偶联受体通过多种蛋白激酶的磷酸化来调节。最近，β-肾上腺素能受体和视紫红质受体活性状态的终止被证明是由蛋白-丝氨酸/苏氨酸激酶(这里称为G蛋白偶联受体激酶)家族的成员通过激动剂或光依赖的磷酸化来介导的。我们现在报道分离出一组编码果蝇蛋白激酶的基因家族，这些基因似乎编码G蛋白偶联受体激酶。这些蛋白质与牛的β-肾上腺素能受体激酶有高度的序列同源性。在脊椎动物和无脊椎动物中存在一个保守的G蛋白偶联受体激酶家族，这表明这些激酶在信号转导级联中起着中心作用。
G protein-coupled receptors are regulated via phosphorylation by a variety of protein kinases. Recently, termination of the active state of two such receptors, the beta-adrenergic receptor and rhodopsin, has been shown to be mediated by agonist- or light-dependent phosphorylation of the receptor by members of a family of protein-serine/threonine kinases (here referred to as G protein-coupled receptor kinases). We now report the isolation of a family of genes encoding a set of Drosophila protein kinases that appear to code for G protein-coupled receptor kinases. These proteins share a high degree of sequence homology with the bovine beta-adrenergic receptor kinase. The presence of a conserved family of G protein-coupled receptor kinases in vertebrates and invertebrates points to the central role of these kinases in signal transduction cascades.