High-NaCl diet reduces cardiac vagal afferent nerve response to volume expansion.
High-NaCl diet reduces cardiac vagal afferent nerve response to volume expansion.
复制标题
高氯化钠饮食会降低心脏迷走神经传入神经对容量扩张的反应。
DOI：
10.1152/ajpregu.1987.252.4.r687
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Sawin,LL
中科院分区：
文献类型：
--
作者：
Dibona,GF;Sawin,LL
为了定位高饮食NaCl摄入降低静脉容量扩张对传出肾交感神经活动的反射抑制作用的机制，在麻醉的正常大鼠中进行实验，准备分别检查心肺压力感受器反射的传入和传出肢体。当左心室舒张末期压，左心充盈压的指数，逐步增加静脉等渗盐水给药sinoclastic-denervated大鼠，心脏迷走神经传入神经活动的增加是在大鼠消耗高相比，正常饮食NaCl摄入量。在电刺激中枢迷走神经sinocentic-denervated大鼠，肾交感神经活动的减少消耗高和正常饮食中的NaCl摄入量的大鼠相似。因此，在静脉容量扩张期间，高饮食NaCl摄入降低整体心肺压力感受性反射增益的作用位于反射弧的传入支。
To localize the mechanism by which high dietary NaCl intake decreases the reflex inhibitory effects of intravenous volume expansion on efferent renal sympathetic nerve activity, experiments were performed in anesthetized normal rats prepared for separate examination of the afferent and efferent limbs of the cardiopulmonary baroreceptor reflex. When left ventricular end-diastolic pressure, an index of left heart filling pressure, was progressively increased by intravenous isotonic saline administration in sinoaortic-denervated rats, the increase in cardiac vagal afferent nerve activity was less in rats consuming high compared with normal dietary NaCl intake. During electrical stimulation of the central vagus nerve in sinoaortic-denervated rats, the decreases in efferent renal sympathetic nerve activity were similar in rats consuming high and normal dietary NaCl intake. Thus the effect of high dietary NaCl intake to decrease overall cardiopulmonary baroreceptor reflex gain during intravenous volume expansion is located in the afferent limb of the reflex arc.