Nanotherapeutic-directed approaches to analgesia.
Nanotherapeutic-directed approaches to analgesia.
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DOI：
10.1016/j.tips.2021.03.007
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发表时间：
2021-07
影响因子：
13.8
通讯作者：
FitzGerald GA
中科院分区：
文献类型：
--
作者：
Mazaleuskaya LL;Muzykantov VR;FitzGerald GA
The ongoing opioid crisis highlighted the need for non-steroidal anti-inflammatory drugs (NSAIDs), non-addictive analgesics against pain, fever and inflammation. However, NSAIDs may cause gastrointestinal and cardiovascular adverse effects. To avoid systemic toxicity and deliver drugs to diseased tissues, nanotechnology methods of NSAID encapsulation have been reported, and some have reached clinical development. Currently, 57 micro- and nanodrugs are approved by the U.S. Food and Drug Administration (FDA). Already approved nanoanalgesics have revealed superior efficacy or reduced toxicity compared to placebo or lower doses of systemically administered active comparators. In this review, the evidence for approval of the marketed nanodrugs will be discussed, with a focus on therapies for pain and inflammation. Nanomedicine remains an attractive field for the development of targeted analgesics.
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