Inclusion-mediated lipid organization in supported membranes on a patterned substrate.
Inclusion-mediated lipid organization in supported membranes on a patterned substrate.
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DOI：
10.1021/jp075167u
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发表时间：
2008-01
期刊：
影响因子：
--
通讯作者：
Q. Liang;Yu-qiang Ma
中科院分区：
文献类型：
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作者：
Q. Liang;Yu-qiang Ma
我们从理论上研究了夹杂物对几何图形衬底上混合脂类双层膜结构域形成的影响。结果表明，夹杂物的体积分数和尺寸不同，夹杂物的分布可能会有很大的不同。包裹体的分布将有效地改变富包涵体脂结构域的自发曲率，从而对支撑双层中的脂结构域进行分类。通过改变包裹体的体积分数和大小，我们得到了丰富的横向排列的脂双层，并揭示了这些结构之间的一些有趣的转变。该模型为控制膜中结构域的形成提供了一种可能的策略，并可能为通过重组脂类和包裹体来设计生物传感器提供一些理论上的见解。
We theoretically investigate the effects of inclusions on the domain formation in mixed lipid bilayers supported on a geometrically patterned substrate. It is found that the inclusions may distribute quite differently with varying volume fraction and size of inclusions. The distribution of inclusions will effectively change the spontaneous curvature of the inclusion-rich lipid domains, and consequently can sort the lipid domains in the supported bilayers. By varying the volume fraction and size of inclusions, we obtain a rich variety of laterally organized lipid bilayers and reveal some interesting transitions between these structures. The present model provides a possible strategy to control the domain formation in the supported membranes, and may yield some theoretical insight into the design of biosensors by the reorganization of lipids and inclusions.