Use of 5,5-(Dimethyl)-i-Pr-PHOX as a Practical Equivalent to t-Bu-PHOX in Asymmetric Catalysis
Use of 5,5-(Dimethyl)-i-Pr-PHOX as a Practical Equivalent to t-Bu-PHOX in Asymmetric Catalysis
复制标题
DOI：
10.1021/ol9005618
复制
发表时间：
2009-05-21
期刊：
影响因子：
5.2
通讯作者：
Paquin, Jean-Francois
中科院分区：
文献类型：
--
作者：
Belanger, Etienne;Pouliot, Marie-France;Paquin, Jean-Francois
报道了5，5(二甲基)-i-Pr-PHOX作为t-Bu-PHOX在不对称催化中的应用。这个新的膦并恶唑啉配体家族的新成员在立体诱导方面表现出与t-Bu-PHOX相似的行为，关键的优点是作为两个从(S)-或(R)-valine开始的对映体都很容易获得。
The use of 5,5(dimethyl)-i-Pr-PHOX as a practical equivalent of t-Bu-PHOX in asymmetric catalysis is reported. This new member of the phosphinooxazoline (PHOX) ligand family behaves similarly in terms of stereoinduction to t-Bu-PHOX with the key advantage of being readily accessible as both enantiomers starting from either (S)- or (R)-valine.