EVALUATION OF ACROMEGALY BY RADIOIMMUNOASSAY OF SOMATOMEDIN-C
EVALUATION OF ACROMEGALY BY RADIOIMMUNOASSAY OF SOMATOMEDIN-C
复制标题
DOI：
10.1056/nejm197911223012102
复制
发表时间：
1979-01-01
影响因子：
158.5
通讯作者：
UNDERWOOD, LE
中科院分区：
文献类型：
--
作者：
CLEMMONS, DR;VANWYK, JJ;UNDERWOOD, LE
用放射免疫法测定57例肢端肥大症患者血清生长调节素C（SM-C）浓度，并与疾病活动性的各种指标进行比较。肢端肥大症患者的平均空腹SM-C浓度为6.8 U[单位]/ml（范围，2.6-21.7），48例正常空腹成人的平均空腹SM-C浓度为0.67 U/ml（范围，0.31-1.4）。SM-C浓度与以下因素显著相关：足跟垫厚度（r [相关系数] = 0.73）、空腹血糖（r = 0.74）和餐后1小时血糖（r = 0.77）。相反，葡萄糖抑制生长激素[GH]与这些严重程度的临床指标弱相关（r = 0.34，0.36，0.34）。空腹GH水平无相关性（r = 0.14）。5例活动性肢端肥大症患者在葡萄糖抑制后GH水平正常，但SM-C升高。在15例患者治疗后1年的研究中，SM-C浓度的变化与临床改善的程度一致。SM-C的测量似乎提供了一个可靠的手段，以确认肢端肥大症的诊断和临床疾病的活动比GH浓度的测量。
Serum concentrations of somatomedin-C [SM-C] were measured by radioimmunoassay in 57 acromegalic patients and compared with various indicators of disease activity. The mean fasting SM-C concentration was 6.8 U[units]/ml (range, 2.6-21.7) for the acromegalics and 0.67 U/ml (range, 0.31-1.4) for 48 normal, fasting adults. The SM-C concentration correlated significantly with: heel-pad thickness (r [correlation coefficient] = 0.73), fasting glucose (r = 0.74), and 1 h postprandial glucose (r = 0.77). In contrast, glucose-suppressed growth hormone [GH] correlated weakly (r = 0.34, 0.36, 0.34) with these clinical indexes of severity. Fasting GH levels showed no correlation (r = 0.14). Five active acromegalics had normal GH levels after glucose suppression, but they had elevated SM-C. In 15 patients studied 1 yr after treatment, changes in SM-C concentrations paralleled the degree of clinical improvement. Measurement of SM-C appears to provide a reliable means for confirming the diagnosis of acromegaly and of clinical disease activity than measurement of GH concentrations.