Trabecular bone remodeling after seven days of weightlessness exposure (BIOCOSMOS 1667).
Trabecular bone remodeling after seven days of weightlessness exposure (BIOCOSMOS 1667).
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DOI：
10.1152/ajpregu.1988.255.2.r243
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发表时间：
1988-08
期刊：
影响因子：
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通讯作者：
L. Vico;D. Chappard;S. Palle;Bakulina Av;Novikov Ve;C. Alexandre
中科院分区：
文献类型：
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作者：
L. Vico;D. Chappard;S. Palle;Bakulina Av;Novikov Ve;C. Alexandre
7只雄性大鼠在苏联的宇宙使命1667中暴露于7天的失重状态，并通过骨组织形态计量学方法与7只对照大鼠进行比较。飞行动物胫骨近端干骺端的骨小梁体积明显减少。骨小梁数量和厚度减少，这可能导致骨力学性能的改变。骨小梁和骨内膜水平的形成活动（通过测量类骨质接缝反映）减少。再吸收活性（使用组织酶学方法通过破骨细胞数量和活性再吸收表面计数估计）保持不变。这些细胞活动之间的不平衡似乎是导致骨小梁骨量丢失的原因。在股骨近端干骺端，在位于肌肉附着点下方的区域进行测量。尽管飞行大鼠的骨小梁体积略有下降，但与对照组大鼠无显著差异。此外，骨密度和类骨质参数不变。这两个长骨之间的差异反应需要进一步的调查。在胸椎和腰椎中，未发现骨量和骨吸收参数的可检测变化。
Seven male rats were exposed to 7 days of weightlessness in the Soviet mission COSMOS 1667 and compared with seven control rats by bone histomorphometric methods. In proximal tibial metaphysis, the trabecular bone volume was markedly reduced in flight animals. Trabeculae were decreased in number and thickness; this probably leads to alteration of bone mechanical properties. Formation activity (reflected by measurements of osteoid seams) was decreased at trabecular and endosteal levels. Resorption activity (estimated by count of osteoclast number and active resorption surfaces using a histoenzymologic method) remained unchanged. The imbalance between these cellular activities appears to be responsible for the loss of trabecular bone mass. In proximal femoral metaphysis, measurements were performed in an area located under the muscular insertions. The trabecular bone volume, despite a slight decrease in flight rats, was not significantly different from that of control rats. Furthermore, osteoclastic and osteoid parameters were unchanged. Differential responses between these two long bones need additional investigations. In thoracic and lumbar vertebrae no detectable change in bone mass and bone resorption parameters was found.