Effect of chronically administered timolol on aqueous humor flow in patients with glaucoma.
Effect of chronically administered timolol on aqueous humor flow in patients with glaucoma.
复制标题
长期服用噻吗洛尔对青光眼患者房水流量的影响。
DOI：
10.1016/s0161-6420(82)34797-1
复制
发表时间：
1982
期刊：
影响因子：
13.7
通讯作者：
Bourne,WM
中科院分区：
文献类型：
--
作者：
Brubaker,RF;Nagataki,S;Bourne,WM
对13名慢性开角型青光眼患者的15只眼睛进行了一项前瞻性分析，探讨长期服用替莫洛依对通过前房的房水流量的影响。治疗一周后，每只治疗眼的血流量均低于治疗前。治疗一年后，15只治疗眼中有13只的血流量低于治疗前。然而，15只眼睛中有12只在治疗一年后的流量高于治疗一周后的流量。这些数据表明，眼睛中的睫状体或其他结构必须部分适应这种药物的长期给药。适应的机制尚不清楚。
A prospective analysis of the effect of chronically administered timoloi on the rate of aqueous humor flow through the anterior chamber was performed in 15 eyes of 13 subjects with chronic openangle glaucoma. After one week's treatment, the flow of each treated eye was lower than it had been prior to treatment. After one year's treatment, the flow of 13 of 15 treated eyes was lower than it had been prior to treatment. However, the flow was higher in 12 of 15 eyes after a year's treatment than it had been after a week's treatment. These data suggest that the ciliary body or other structures in the eye must partly adapt to the chronic administration of this drug. The mechanism of the adaptation is unknown.