Metabolic genes in cancer: their roles in tumor progression and clinical implications.
Metabolic genes in cancer: their roles in tumor progression and clinical implications.
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DOI：
10.1016/j.bbcan.2010.01.005
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发表时间：
2010-04
影响因子：
11.2
通讯作者：
Watabe, Kounosuke
中科院分区：
文献类型：
--
作者：
Furuta, Eiji;Okuda, Hiroshi;Kobayashi, Aya;Watabe, Kounosuke
代谢途径的重新编程是癌细胞生理变化的标志。直接控制关键代谢途径（包括糖酵解、脂肪生成和核苷酸合成）速率的某些基因的表达在肿瘤进展的不同阶段急剧改变。这些改变通常被认为是肿瘤细胞的适应;然而，它们也有助于肿瘤细胞的进展，使其变得更具侵袭性的表型。本文综述了这些基因与肿瘤发生的机制联系及其作为诊断标志物和治疗靶点的潜在用途。我们特别关注三组基因：糖酵解途径中的GLUT 1，G6 PD，TKTL 1和PGI/AMF，脂肪生成中的ACLY，ACC 1和FAS以及核苷酸合成中的RRM 1，RRM 2和TYMS。所有这些基因在癌症患者的多种肿瘤细胞中高度上调，并且它们在肿瘤进展中发挥积极作用，而不仅仅是作为癌细胞表型变化的结果而表达。对它们的协调网络进行分子解剖并了解它们表达的确切机制将为靶向这些基因进行特定癌症治疗提供机会之窗。我们还回顾了现有的基因芯片数据库，以验证这些基因在癌症诊断中的实用性。
Re-programming of metabolic pathways is a hallmark of physiological changes in cancer cells. The expression of certain genes that directly control the rate of key metabolic pathways including glycolysis, lipogenesis and nucleotide synthesis are drastically altered at different stages of tumor progression. These alterations are generally considered as an adaptation of tumor cells; however, they also contribute to the progression of tumor cells to become more aggressive phenotypes. This review summarizes the recent information about the mechanistic link of these genes to oncogenesis and their potential utility as diagnostic markers as well as for therapeutic targets. We particularly focus on three groups of genes; GLUT1, G6PD, TKTL1 and PGI/AMF in glycolytic pathway, ACLY, ACC1 and FAS in lipogenesis and RRM1, RRM2 and TYMS for nucleotide synthesis. All these genes are highly up-regulated in a variety of tumor cells in cancer patients, and they play active roles in tumor progression rather than expressing merely as a consequence of phenotypic change of the cancer cells. Molecular dissection of their orchestrated networks and understanding the exact mechanism of their expression will provide a window of opportunity to target these genes for specific cancer therapy. We also reviewed existing database of gene microarray to validate the utility of these genes for cancer diagnosis.
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影响因子：
4
作者：
BIANCHI, A;EVANS, JL;WITTERS, LA
通讯作者：
WITTERS, LA
影响因子：
8
作者：
Bandyopadhyay, S;Pai, SK;Watabe, K
通讯作者：
Watabe, K
DOI：
10.1073/pnas.0931394100
发表时间：
2003-05-27
影响因子：
11.1
作者：
Chirala, SS;Chang, H;Wakil, SJ
通讯作者：
Wakil, SJ
影响因子：
11.2
作者：
Chajes, Veronique;Cambot, Marie;Joulin, Virginie
通讯作者：
Joulin, Virginie
影响因子：
8
作者：
Chen, M.;Rahman, L.;Zajac-Kaye, M.
通讯作者：
Zajac-Kaye, M.