Role of fibroblast growth factors in bone regeneration.
Role of fibroblast growth factors in bone regeneration.
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DOI：
10.1186/s41232-017-0043-8
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发表时间：
2017
影响因子：
8.1
通讯作者：
Iseki S
中科院分区：
文献类型：
--
作者：
Charoenlarp P;Rajendran AK;Iseki S
骨是一个代谢活跃的器官，在整个生命过程中不断重塑。然而，许多复杂的骨缺损，如大的创伤性骨缺损或肿瘤切除后广泛的骨丢失，可能会导致骨愈合失败。这些病症的有效疗法通常采用细胞、支架和生物活性因子的组合。在本文中，我们关注骨再生所需的三个因素之一，生物活性因子，特别是成纤维细胞生长因子（FGF）家族。该家族由22个成员组成，与包括骨骼形成在内的各种生物学功能相关。基于遗传修饰小鼠的表型和骨折愈合期间的时空表达水平，FGF 2、FGF 9和FGF 18被认为是可用于骨再生的可能候选物。这些候选FGF在骨再生中的作用也在本文中进行了讨论。
Bone is a metabolically active organ that undergoes continuous remodeling throughout life. However, many complex skeletal defects such as large traumatic bone defects or extensive bone loss after tumor resection may cause failure of bone healing. Effective therapies for these conditions typically employ combinations of cells, scaffolds, and bioactive factors. In this review, we pay attention to one of the three factors required for regeneration of bone, bioactive factors, especially the fibroblast growth factor (FGF) family. This family is composed of 22 members and associated with various biological functions including skeletal formation. Based on the phenotypes of genetically modified mice and spatio-temporal expression levels during bone fracture healing, FGF2, FGF9, and FGF18 are regarded as possible candidates useful for bone regeneration. The role of these candidate FGFs in bone regeneration is also discussed in this review.