Microinjections of dopamine agonists and cocaine elevate plasma corticosterone: dissociation effects among the ventral and dorsal striatum and medial prefrontal cortex
Microinjections of dopamine agonists and cocaine elevate plasma corticosterone: dissociation effects among the ventral and dorsal striatum and medial prefrontal cortex
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DOI：
10.1016/s0006-8993(98)01070-1
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发表时间：
1998-12-14
期刊：
影响因子：
2.9
通讯作者：
Goeders, NE
中科院分区：
文献类型：
--
作者：
Ikemoto, S;Goeders, NE
有证据表明中枢多巴胺（DA）系统参与血浆皮质酮（CORT）的调节。我们研究了是否DA激动剂和可卡因微量注射到三个DA丰富的终端区域，内侧前额叶皮层（MPC），腹侧纹状体（VStr）和背侧纹状体（DStr），将增加血浆CORT在Sprague-Dawley大鼠。当将多巴胺D-1受体激动剂SKF 38393和D-2激动剂喹吡罗（SKF/Quin）的混合物注射到三个脑区中的每一个时，测试的最高剂量（18 nmol）增加了血浆CORT。微量注射中等剂量（即，3 nmol）SKF/Quin也增加了血浆CORT，而MPC和DStr中的注射没有增加。氟哌啶醇全身预处理可减弱VStr内注射SKF/Quin诱导的CORT升高。当注射到VStr中时，钴（25、50和100 μ g）也增加CORT，但不增加MPC或DStr。局部麻醉药，利多卡因（100 μ g）和普鲁卡因（100 μ g），具有类似的化学结构，到VStr的微量注射，没有增加CORT。这些结果表明，VStr在介导DA受体激动剂和可卡因引起的血浆CORT升高中起重要作用。(C)1998 Elsevier Science B. V.保留所有权利。
There is evidence suggesting the involvement of central dopamine (DA) systems in the regulation of plasma corticosterone (CORT). We examined whether or not microinjections of DA agonists and cocaine into three DA-rich terminal regions, the medial prefrontal cortex (MPC), ventral striatum (VStr) and dorsal striatum (DStr), would increase plasma CORT in Sprague-Dawley rats. The highest dose tested (18 nmol) of a mixture of the dopamine D-1 receptor agonist SKF 38393 and the D-2 agonist quinpirole (SKF/Quin) increased plasma CORT when injected into each of the three brain regions. Microinjections of the medium dose (i.e., 3 nmol) of SKF/Quin into the VStr also increased plasma CORT, while the injections into the MPC and DStr did not. Systemic pretreatment with haloperidol attenuated the elevated CORT induced by intra-VStr injections of SKF/Quin. Cocaine (25, 50, and 100 mu g) also increased CORT when injected into the VStr, but not into the MPC or DStr. Microinjections of local anesthetics, lidocaine (100 mu g) and procaine (100 mu g), which have similar chemical structures to cocaine, into the VStr did not increase CORT. These results suggest that the VStr plays an important role in mediating the elevated plasma CORT induced by DA agonists and cocaine administration. (C) 1998 Elsevier Science B.V. All rights reserved.