Carbohydrate deficient transferrin (CDT) in alcoholic cirrhosis: A kinetic study
Carbohydrate deficient transferrin (CDT) in alcoholic cirrhosis: A kinetic study
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DOI：
10.1016/s0168-8278(97)80043-8
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发表时间：
1997-02-01
影响因子：
25.7
通讯作者：
Becker, U
中科院分区：
文献类型：
--
作者：
Henriksen, JH;Gronbaek, M;Becker, U
背景/目的：糖缺乏性转铁蛋白已被认为是过量饮酒的标志，本研究旨在检测酒精性肝硬变患者血中糖缺乏性转铁蛋白的循环水平，评价肝、肾动静脉动力学变化。方法/结果：41例酒精性肝硬变患者血清糖缺乏性转铁蛋白的中位数为16.0U/L，与正常对照组(中位数17.4U/L，n=55，ns)无显著差异。碳水化合物缺乏转铁蛋白在肝硬变和高饮酒者中显著高于戒酒患者(20U/L，14U/天，p50g/天)，碳水化合物缺乏转铁蛋白浓度显著高于低酒精摄入量对照组(P
Background/Aims: Carbohydrate deficient transferrin has been introduced as a marker of excessive alcohol intake, The present study was undertaken in order to measure the circulating level of carbohydrate deficient transferrin in patients with alcoholic cirrhosis and to assess arteriovenous kinetics of carbohydrate deficient transferrin in liver and kidney.Methods/Results: The median value of serum carbohydrate deficient transferrin was 16.0 U/l in patients with alcoholic cirrhosis (n=41), and this value was not significantly different from that of a normal control group (median 17.4 U/l, n=55, ns), Carbohydrate deficient transferrin was significantly higher in patients with cirrhosis and high current alcohol intake than in abstaining patients (20 vs. 14 U/l, p50 g/day) had a significantly higher carbohydrate deficient transferrin concentration than controls with a low alcohol intake (