Multiple sessions of transcranial direct current stimulation to the intact hemisphere improves visual function after unilateral ablation of visual cortex.
Multiple sessions of transcranial direct current stimulation to the intact hemisphere improves visual function after unilateral ablation of visual cortex.
复制标题
单侧视觉皮层消融后，对完整半球进行多次经颅直流电刺激可改善视觉功能。
DOI：
10.1111/ejn.12373
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Valero-Cabré,A
中科院分区：
文献类型：
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作者：
Rushmore,RJ;DeSimone,C;Valero-Cabré,A
脑系统受损后通常会出现补偿机制，以减轻脑损伤的影响并恢复功能。然而，内在恢复很少是完全的。非侵入性脑刺激技术有可能积极塑造神经回路并增强脑损伤的恢复。在这项研究中，一个稳定的赤字检测和定向的视觉刺激呈现在contralesional视觉半野产生的右侧后顶叶和连续的视觉皮层区域的单侧脑损伤。对对侧（完整）后顶叶皮质施加长期抑制性无创经颅直流电刺激（阴极tDCS，2 mA，20 min），持续14周（共70次，每天1次，每周5天），并定期评估行为结局。在四只受刺激的猫中，观察到视觉空间功能的持久恢复。刺激2-3周后开始恢复，恢复的目标首先位于周边，并随着刺激会话的增加移动到更中心的视野位置。运动任务的恢复在达到平台水平之前遵循双相模式。恢复没有发生更困难的视觉任务。这些发现强调了多次经颅直流电刺激在单侧脑损伤后恢复视觉空间功能的能力。
Damage to cerebral systems is frequently followed by the emergence of compensatory mechanisms, which serve to reduce the effects of brain damage and allow recovery of function. Intrinsic recovery, however, is rarely complete. Non‐invasive brain stimulation technologies have the potential to actively shape neural circuits and enhance recovery from brain damage. In this study, a stable deficit for detecting and orienting to visual stimuli presented in the contralesional visual hemifield was generated by producing unilateral brain damage of the right posterior parietal and contiguous visual cortical areas. A long regimen of inhibitory non‐invasive transcranial direct‐current stimulation (cathodal tDCS, 2 mA, 20 min) was applied to the contralateral (intact) posterior parietal cortex over 14 weeks (total of 70 sessions, one per day, 5 days per week) and behavioral outcomes were periodically assessed. In three out of four stimulated cats, lasting recovery of visuospatial function was observed. Recovery started after 2–3 weeks of stimulation, and recovered targets were located first in the periphery, and moved to more central visual field locations with the accrual of stimulation sessions. Recovery for moving tasks followed a biphasic pattern before reaching plateau levels. Recovery did not occur for more difficult visual tasks. These findings highlight the ability of multiple sessions of transcranial direct‐current stimulation to produce recovery of visuospatial function after unilateral brain damage.