DECIDUAL NATURAL-KILLER CYTOTOXICITY DECREASED IN NORMAL-PREGNANCY BUT NOT IN ANEMBRYONIC PREGNANCY AND RECURRENT SPONTANEOUS-ABORTION
DECIDUAL NATURAL-KILLER CYTOTOXICITY DECREASED IN NORMAL-PREGNANCY BUT NOT IN ANEMBRYONIC PREGNANCY AND RECURRENT SPONTANEOUS-ABORTION
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DOI：
10.1111/j.1600-0897.1995.tb00953.x
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发表时间：
1995-11-01
影响因子：
3.6
通讯作者：
GILL, TJ
中科院分区：
文献类型：
--
作者：
CHAO, KH;YANG, YS;GILL, TJ
问题：自然杀伤（NK）细胞活性在正常妊娠早期的蜕膜中受到抑制。最近Morii et al.（Am J Reprod Immunol 1993;29：1-4）发现所有早期蜕膜内CD 3（+）T细胞表达T细胞受体（TCR）α/β或γ/δ，但CD 3（+）/TCR复合物的表达下调。为探讨正常妊娠、无胚妊娠和反复自然流产患者蜕膜细胞免疫功能的变化是否存在差异，我们使用流式细胞术和NK细胞毒性试验检测了这三种妊娠类型蜕膜中的免疫细胞亚群。蜕膜内CD 3（+）T细胞表达TCR α/β或γ/δ，在正常妊娠、无胚妊娠和复发性自然流产中，CD 3/TCR复合物的表达水平下调。虽然蜕膜NK细胞的相对比例增加到大约相同的程度，在所有三种类型的妊娠，蜕膜NK活性较高，在无胚妊娠和复发性自然流产比它是在normal pregnances.CONCLUSION：蜕膜NK细胞反应是不同的无胚妊娠和复发性自然流产比正常妊娠。这种差异是致病性的还是对死亡胚胎的反应仍有待阐明。
PROBLEM: The natural killer (NK) cell activity is depressed in the decidua of early normal pregnancy. Recently Morii et al. (Am J Reprod Immunol 1993;29:1-4) found that all early intradecidual CD3(+) T cells expressed either T cell receptor (TCR) alpha/beta or gamma/delta but that the expression of the CD3(+)/TCR complex was down-regulated.METHOD: To test whether these changes in decidual cellular immunity are different among normal pregnancy, anembryonic pregnancy and recurrent spontaneous abortion, we examined the immune cell subpopulations in the decidua from these three types of pregnancy using flow cytometry and an NK cytotoxicity assay.RESULTS: Intradecidual CD3(+) T cells expressed either TCR alpha/beta or gamma/delta and the level of expression of the CD3/TCR complex was down-regulated in normal pregnancy, anembryonic pregnancy, and recurrent spontaneous abortion. Although the relative proportion of decidual NK cells was increased to approximately the same extent in all three types of pregnancy, decidual NK activity was higher in anembryonic pregnancies and in recurrent spontaneous abortions than it was in normal pregnancies.CONCLUSION: Decidual NK cell responses are different in anembryonic pregnancies and in recurrent spontaneous abortions than in normal pregnancies. Whether this difference is pathogenic or is the response to a dead embryo remains to be elucidated.