Heart Failure With Preserved Ejection Fraction In Perspective
Heart Failure With Preserved Ejection Fraction In Perspective
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DOI：
10.1161/circresaha.119.313572
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发表时间：
2019-05-24
影响因子：
20.1
通讯作者：
Borlaug, Barry A.
中科院分区：
文献类型：
--
作者：
Pfeffer, Marc A.;Shah, Amil M.;Borlaug, Barry A.
大约一半有心力衰竭体征和症状的患者的左心室射血分数没有明显异常。尽管历史上最初的惊喜，但心力衰竭的风险增加，具体的主要不良事件发生在射血分数的广泛范围内，包括正常。在过去的20年里，人们对射血分数保留的心力衰竭问题的严重性的认识，刺激了临床研究的爆炸性增长，以及越来越多的信息性结果试验。本文介绍了心力衰竭综合征的这一组成部分的历史发展，包括流行病学、病理生理学和现有的和计划中的治疗研究。展望未来，对亚群进行更具体的表型，甚至基因分型，应该会改善未来试验的结果。
Approximately half of the patients with signs and symptoms of heart failure have a left ventricular ejection fraction that is not markedly abnormal. Despite the historically initial surprise, heightened risks for heart failure specific major adverse events occur across the broad range of ejection fraction, including normal. The recognition of the magnitude of the problem of heart failure with preserved ejection fraction in the past 20 years has spurred an explosion of clinical investigation and growing intensity of informative outcome trials. This article addresses the historic development of this component of the heart failure syndrome, including the epidemiology, pathophysiology, and existing and planned therapeutic studies. Looking forward, more specific phenotyping and even genotyping of subpopulations should lead to improvements in outcomes from future trials.