PASADENA hyperpolarized 13C phospholactate.
PASADENA hyperpolarized 13C phospholactate.
复制标题
PASADENA 超极化 13C 磷酸乳酸。
DOI：
10.1021/ja210639c
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发表时间：
2012
影响因子：
15
通讯作者：
Chekmenev,EduardY
中科院分区：
文献类型：
--
作者：
Shchepin,RomanV;Coffey,AaronM;Waddell,KevinW;Chekmenev,EduardY
我们证明，钾1- 13 C-磷酸烯醇丙酮酸成为超极化钾1- 13 C-磷酸乳酸与13 CT 1 = 36秒后，分子氢化PASADENA（仲氢和合成允许显着增强核排列）。该原理验证研究是用完全质子化的分子生物传感器进行的。13 C被极化到1%的水平，相当于在3 T下灵敏度提高近4000倍。相关的同质和异质自旋自旋耦合的报告。
We demonstrate that potassium 1-13C-phosphoenolpyruvate becomes hyperpolarized potassium 1-13C-phospholactate with13CT1= 36 s after molecular hydrogenation by PASADENA (Parahydrogen and Synthesis Allows Dramatically Enhanced Nuclear Alignment). This proof-of-principle study was conducted with a fully protonated molecular precursor.13C was polarized to a level of 1%, corresponding to nearly 4000-fold sensitivity enhancement at 3 T. The relevant homo- and heteronuclear spin–spin couplings are reported.