Preclinical evaluation of gadolinium (III) texaphyrin complex. A new paramagnetic contrast agent for magnetic resonance imaging.
Preclinical evaluation of gadolinium (III) texaphyrin complex. A new paramagnetic contrast agent for magnetic resonance imaging.
复制标题
钆 (III) 泰克萨菲林复合物的临床前评估。
DOI：
10.1097/00004424-199403000-00013
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发表时间：
1994
影响因子：
6.7
通讯作者：
Mutch,JD
中科院分区：
文献类型：
--
作者：
Young,SW;Sidhu,MK;Qing,F;Muller,HH;Neuder,M;Zanassi,G;Mody,TD;Hemmi,G;Dow,W;Mutch,JD
基本原理和目的。对钆 III 泰克萨菲林 (Gd [III] 泰克萨菲林) 复合物（一种新型磁共振成像造影 (MRI) 剂）进行了评估。方法。进行了体外弛豫度 (1.5 T) 和稳定性研究（5% 葡萄糖）。亚慢性毒性（8只雄性，8只雌性；2-20（μmol Gd（III）泰克萨菲林复合物/kg体重；每周3次，持续3周）。在Sprague-Dawley大鼠中进行生物分布和排泄研究；在正常和荷瘤大鼠和兔子中进行MRI研究。结果。松弛度值如下：1= 19（μmol/L·sec）-1和r2= 22 (μmol/L·秒)-1 21 天的亚慢性毒性研究显示，该化合物在正常 (n= 34) 和荷瘤 (n= 4) 大鼠以及正常 (n= 8) 和荷瘤 (n= 19) 兔子中的生物分布显示稳定：1-17 µmol/kg 后肝脏和肾脏的对比度显着增强。 Gd (III) texaphyrin 复合物 (2.5 (μmol/kg)) 对兔子 (n= 8) 的肝癌产生显着的对比增强。大腿 V2 癌 (n= 22) 具有选择性 (P<. 05) 增强，5 µmol/kg。在大鼠纤维肉瘤 (n= 4) 中，17 (μmol Gd (III) texaphyrin 复合物。结论。钆 (III) 泰克萨菲林复合物似乎是一种有效且安全的 MRI 造影剂。© Lippincott-Raven Publishers。返回顶部当前期刊封面图片决不会错过一期获取新期刊目录直接发送到您的电子邮件收件箱获取新期刊警报浏览期刊内容
RATIONALE AND OBJECTIVES.Gadolinium III texaphyrin (Gd [III] texaphyrin) complex, a new magnetic resonance imaging contrast (MRI) agent, was evaluated.METHODS.In vitro relaxivity (1.5 T) and stability studies (5% dextrose) were conducted. Subchronic toxicity (8 males, 8 females; 2-20 (µmol Gd (III) texaphyrin complex/kg body weight; 3 times per week for 3 weeks). Biodistribution and excretion studies were conducted in Sprague-Dawley rats; MRI studies were conducted in normal and tumor-bearing rats and rabbits.RESULTS.Relaxivity values were as follows: 1= 19 (µmol/L· sec)-1 and r2= 22 (µmol/L· sec)-1 The 21-day subchronic toxicity study revealed no abnormalities. The compound is stable. Biodistribution demonstrated liver uptake. Magnetic resonance imaging in normal (n= 34) and tumorbearing (n= 4) rats and normal (n= 8) and tumor-bearing (n= 19) rabbits revealed: significant (P<. 05) contrast enhancement of liver and kidney after 1-17 µmol/kg of Gd (III) texaphyrin complex. Gadolinium (III) texaphyrin complex (2.5 (µmol/kg) produced significant contrast enhancement of liver carcinomas in rabbits (n= 8). Thigh V2 carcinomas (n= 22) had selective (P<. 05) enhancement, 5 µmol/kg. In rat fibro-sarcomas (n= 4), 17 (µmol Gd (III) texaphyrin complex produced significant enhancement up to 24 hours.CONCLUSIONS.Gadolinium (III) texaphyrin complex appears to be an effective and safe MRI contrast agent.© Lippincott-Raven Publishers.Back to TopCurrent Issue Cover ImageNever Miss an IssueGet new journal Tables of Contents sent right to your email inboxGet New Issue AlertsBrowse Journal Content