AXONAL ELONGATION INTO PERIPHERAL NERVOUS-SYSTEM BRIDGES AFTER CENTRAL NERVOUS-SYSTEM INJURY IN ADULT-RATS
AXONAL ELONGATION INTO PERIPHERAL NERVOUS-SYSTEM BRIDGES AFTER CENTRAL NERVOUS-SYSTEM INJURY IN ADULT-RATS
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DOI：
10.1126/science.6171034
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
AGUAYO, AJ
中科院分区：
文献类型：
--
作者：
DAVID, S;AGUAYO, AJ
采用一种新的实验模型，观察了成年大鼠局灶性中枢神经系统损伤后轴突生长的起始、终止和长度。当周围神经节段被用作延髓和脊髓之间的桥梁时，来自这两个水平的神经元的轴突生长了大约30毫米。当中枢神经系统的神经胶质环境改变到周围神经系统时，这些中枢神经元的再生潜力似乎就表现出来了。
The origin, termination and length of axonal growth after focal CNS injury was examined in adult rats by means of a new experimental model. When peripheral nerve segments were used as bridges between the medulla and spinal cord, axons from neurons at both these levels grew approximately 30 mm. The regenerative potential of these central neurons seems to be expressed when the CNS glial environment is changed to that of the peripheral nervous system.