The relationship between knee adduction moment and cartilage and meniscus morphology in women with osteoarthritis
The relationship between knee adduction moment and cartilage and meniscus morphology in women with osteoarthritis
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DOI：
10.1016/j.joca.2010.04.006
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发表时间：
2010-07-01
影响因子：
7
通讯作者：
Singh, M. A. Fiatarone
中科院分区：
文献类型：
--
作者：
Vanwanseele, B.;Eckstein, F.;Singh, M. A. Fiatarone
目的：本研究旨在探讨女性膝关节骨性关节炎（OA）患者膝关节内收力矩和内收角冲动与半月板、软骨和骨形态的关系。采用三维运动分析系统对步态过程中膝关节负荷进行评估。采用冠状位T2加权自旋回波序列的3特斯拉磁共振成像（MRI）评价半月板病理，冠状位T1加权梯度回波序列用于量化软骨形态和骨表面大小。使用定制软件测量股胫关节的肱骨厚度、裸露面积和软骨下面积。结果：内侧撕裂的参与者膝关节内收力矩峰值高于外侧撕裂的参与者（2.92 +/- 1.06 vs 0.46 +/- 1.7，P < 0.001）。膝关节内收力矩越大，内侧半月板突出越大（r = 0.532，P < 0.001），内侧半月板高度越低（r =-0.395，P = 0.010）。观察到外侧半月板的反向关系。膝关节内收力矩越大，胫骨软骨下骨内外侧面积比值越大（r = 0.270，P = 0.035）。相比之下，股骨和胫骨的软骨厚度和裸露面积与膝关节内收力矩无关。膝关节内收角冲动和半月板，软骨和骨morphology.Conclusions之间的关系也发现了类似的结果：动态膝关节负荷是显着相关的半月板病理和骨大小，但不与软骨厚度在女性OA。(C)2010年国际骨关节炎研究学会。由爱思唯尔有限公司出版。保留所有权利。
Objective: The aim of this cross-sectional study is to investigate the relationship between knee adduction moment and knee adduction angular impulse and meniscus, cartilage and bone morphology in women with knee osteoarthritis (OA).Method: Forty-five women aged >40 years with OA in at least one knee, according to American College of Rheumatology clinical criteria were studied. The knee joint loading was assessed by three-dimensional motion analysis system during gait. Three Tesla magnetic resonance imaging (MRI) with a coronal T2-weighted spin echo sequence was used for evaluating meniscus pathology, and a coronal T1-weighted gradient echo sequence for quantifying cartilage morphology and bone surface size. Cartilage thickness, denuded area and subchondral area in the femorotibial joint was measured using custom software.Results: A higher peak knee adduction moment was observed in participants with medial compared to those with lateral tears (2.92 +/- 1.06 vs 0.46 +/- 1.7, P < 0.001). Participants with a higher knee adduction moment displayed a larger medial meniscus extrusion (r = 0.532, P < 0.001) and a lower medial meniscus height (r = -0.395, P = 0.010). The inverse relationship was observed for the lateral meniscus. A higher knee adduction moment was also associated with a higher ratio of the medial to lateral tibial subchondral bone area (r = 0.270, P = 0.035). By contrast, cartilage thickness and denuded areas in the femur and tibia were not related to the knee adduction moment. Similar results were found for the relationship between knee adduction angular impulse and meniscus, cartilage and bone morphology.Conclusions: Dynamic knee joint loading is significantly related to meniscus pathology and bone size, but not to cartilage thickness in women with OA. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.