Small Molecule Nanodrug Assembled of Dual-Anticancer Drug Conjugate for Synergetic Cancer Metastasis Therapy
Small Molecule Nanodrug Assembled of Dual-Anticancer Drug Conjugate for Synergetic Cancer Metastasis Therapy
复制标题
小分子纳米药物组装双抗癌药物偶联物协同治疗癌症转移
DOI：
10.1021/acs.bioconjchem.8b00657
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发表时间：
2018-10-01
影响因子：
4.7
通讯作者：
Shao, Jingwei
中科院分区：
文献类型：
--
作者：
Li, Chao;Lin, Juanfang;Shao, Jingwei
基于纳米载体的递送系统已经成为癌症治疗的有希望的候选者;然而，它们的质量问题、批次之间的变化以及载体相关的毒性问题限制了它们的临床应用。与传统的纳米载体相比，无载体纳米药物传递系统克服了这些缺点，在生物医学和纳米技术领域具有广泛的应用前景。本论文以经典药物阿司匹林和天然植物药UA为原料，采用绿色、简单的方法制备了一种新型的无载体纳米药物Asp-UA。研究了Asp-UA NP的形状、粒度、zeta电位、稳定性和紫外-可见光谱吸收。细胞摄取实验表明Asp-UA NPs能被HepG 2细胞内化;细胞实验表明Asp-UA NPs在体外和体内均具有较好的肿瘤转移抑制效果，且毒性较低。此外，Asp-UA纳米粒在体内可明显抑制H22细胞的转移进程。总的来说，Asp-UA NP具有多种优势，有望成为癌症转移治疗的替代方案。
The nanocarrier-based delivery system has emerged as a promising candidate for cancer therapy; nevertheless, their quality problems, variation between batches, and carrier-related toxicity issues have restricted their clinical utilization. Compared with traditional carrier-based nanoparticles, carrier-free nanodrug delivery systems preferred to overcome all these drawbacks and will have a wide range of applications in biomedicine and nanotechnology. Herein, we developed a novel carrier-free nanodrug Asp-UA consisted of the classical drug aspirin and the natural plant drug UA via a green and simple approach. The Asp-UA NPs were investigated for shape, particle size, zeta potential, stability, and UV-vis spectroscopy absorption. Cellular uptake study showed that Asp-UA NPs could be easily internalized by HepG2 cells; cellular study demonstrated that Asp-UA NPs held better inhibitory efficiency on tumor metastasis with low toxicity in vitro and in vivo. Moreover, Asp-UA NPs could obviously suppress the progress of cancer metastasis by H22 cells in vivo. Overall, Asp-UA NPs possess a variety of advantages and hold promise to become an alternative to the treatment of cancer metastasis.